Computed tomographic evaluation of patients with tardive dyskinesia

William F. Hoffman, Daniel E. Casey

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


X ray computed tomography has been used since its introduction to evaluate patients with tardive dyskinesia (TD). A critical review of the 18 reports which have appeared since 1976 suggests that TD may be associated with neuroanatomical abnormalities. In particular, a meta-analysis of the reports of ventricular brain ratio found a trend for patients with TD to have larger lateral ventricles than unaffected patients. The magnitude of the difference appears to be small, however, and several well conducted studies have reported negative results. A careful analysis revealed that low statistical power, concurrent neuroleptic treatment, insensitive measures of ventricular dilatation, and variable diagnostic criteria for TD may have led to negative findings in most of the investigations. The possible significance of these results and suggestions for further research are discussed.

Original languageEnglish (US)
Pages (from-to)1-22
Number of pages22
JournalSchizophrenia Research
Issue number1
StatePublished - 1991
Externally publishedYes


  • Computed tomography
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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