Concepts in Musculoskeletal Bone and Soft Tissue Biopsy

Megan K. Mills, Richard L. Leake, Amanda M. Crawford, Maryam Soltanolkotabi, Barry G. Hansford

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Imaging-guided needle biopsy of musculoskeletal lesions is a high-yield and low-risk procedure that can be used for definitive characterization of indeterminate bone and soft tissue lesions. Familiarity with the preprocedural, technical, and postprocedural steps is vital for the appropriate management of these cases. Biopsy request triage requires an awareness of definitively benign conditions and other tumor mimics. A complete clinical, laboratory, and imaging work-up is essential for procedural planning and determining pathologic concordance. Consultation with an orthopaedic oncologist is a requisite step to ensure maximizing biopsy yield and to avoid interference with any future limb-sparing surgical intervention. Knowledge of the equipment, pertinent medications, and appropriate biopsy technique can minimize the risk of periprocedural complications. Finally, the radiologist may be required to discuss the concordance of histopathology with preprocedure imaging, perform repeat image-guided biopsy, and carefully interpret sarcoma surveillance imaging examinations.

Original languageEnglish (US)
Pages (from-to)711-724
Number of pages14
JournalSeminars in Musculoskeletal Radiology
Issue number6
StatePublished - Dec 22 2021


  • biopsy
  • sarcoma
  • tumor

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging


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