TY - JOUR
T1 - Conceptual Model to Illustrate the Symptom Experience and Humanistic Burden Associated with Atopic Dermatitis in Adults and Adolescents
AU - Grant, Laura
AU - Seiding Larsen, Lotte
AU - Trennery, Claire
AU - Silverberg, Jonathan I.
AU - Abramovits, William
AU - Simpson, Eric L.
AU - Stalder, Jean Francois
AU - Paty, Jean
AU - Hahn-Pedersen, Julie
AU - Kragh, Nana
AU - Bang, Bo
AU - Arbuckle, Rob
N1 - Funding Information:
The work was sponsored and funded by MedImmune and LEO Pharma A/S. J.P. was an employee of ERT and later IQVIA, a consultancy paid by MedImmune and LEO Pharma A/S to conduct the study. L.G., C.T., and R.A. were employees of Adelphi Values, a consultancy paid by LEO Pharma A/S to conduct the study and develop the article. B.B., L.S.L., N.K., and J.H.-P. are employees of LEO Pharma.
Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Atopic dermatitis (AD) is a pruritic or painful dermatologic disease characterized by xerosis and eczema lesions. The symptoms/signs of AD can significantly impact patients' health-related quality of life (HRQoL). This study aimed to qualitatively explore the adult and adolescent experience of AD. A targeted literature review and qualitative concept elicitation interviews with clinicians (n = 5), adult AD patients (n = 28), and adolescent AD patients (n = 20) were conducted to elicit AD signs/symptoms and HRQoL impacts experienced. Verbatim transcripts were analyzed using thematic analysis. Twenty-nine symptoms/signs of AD were reported, including pruritus, pain, erythema, and xerosis. Atopic dermatitis symptoms/signs were reported to substantially impact HRQoL. Scratching was reported to influence the experience of symptoms and HRQoL impacts. Four proximal impacts (including discomfort and sleep disturbance) were reported. Ten domains of distal impact were reported, including impacts on psychological and social functioning and activities of daily living. A conceptual model was developed to summarize these findings. This study highlights the range of symptoms and HRQoL impacts experienced by adults and adolescents with AD. To our knowledge, this study was first to explore the lived experience of AD in both adult and adolescent patients, providing valuable insight into the relatively unexplored adolescent experience of AD.
AB - Atopic dermatitis (AD) is a pruritic or painful dermatologic disease characterized by xerosis and eczema lesions. The symptoms/signs of AD can significantly impact patients' health-related quality of life (HRQoL). This study aimed to qualitatively explore the adult and adolescent experience of AD. A targeted literature review and qualitative concept elicitation interviews with clinicians (n = 5), adult AD patients (n = 28), and adolescent AD patients (n = 20) were conducted to elicit AD signs/symptoms and HRQoL impacts experienced. Verbatim transcripts were analyzed using thematic analysis. Twenty-nine symptoms/signs of AD were reported, including pruritus, pain, erythema, and xerosis. Atopic dermatitis symptoms/signs were reported to substantially impact HRQoL. Scratching was reported to influence the experience of symptoms and HRQoL impacts. Four proximal impacts (including discomfort and sleep disturbance) were reported. Ten domains of distal impact were reported, including impacts on psychological and social functioning and activities of daily living. A conceptual model was developed to summarize these findings. This study highlights the range of symptoms and HRQoL impacts experienced by adults and adolescents with AD. To our knowledge, this study was first to explore the lived experience of AD in both adult and adolescent patients, providing valuable insight into the relatively unexplored adolescent experience of AD.
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U2 - 10.1097/DER.0000000000000486
DO - 10.1097/DER.0000000000000486
M3 - Article
C2 - 31261226
AN - SCOPUS:85069511177
SN - 1710-3568
VL - 30
SP - 247
EP - 254
JO - Dermatitis : contact, atopic, occupational, drug
JF - Dermatitis : contact, atopic, occupational, drug
IS - 4
ER -