Concise review: Parthenote stem cells for regenerative medicine: Genetic, epigenetic, and developmental features

Brittany Daughtry, Shoukhrat Mitalipov

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Embryonic stem cells (ESCs) have the potential to provide unlimited cells and tissues for regenerative medicine. ESCs derived from fertilized embryos, however, will most likely be rejected by a patient's immune system unless appropriately immunomatched. Pluripotent stem cells (PSCs) genetically identical to a patient can now be established by reprogramming of somatic cells. However, practical applications of PSCs for personalized therapies are projected to be unfeasible because of the enormous cost and time required to produce clinical-grade cells for each patient. ESCs derived from parthenogenetic embryos (pESCs) that are homozygous for human leukocyte antigens may serve as an attractive alternative for immunomatched therapies for a large population of patients. In this study, we describe the biology and genetic nature of mammalian parthenogenesis and review potential advantages and limitations of pESCs for cell-based therapies.

Original languageEnglish (US)
Pages (from-to)290-298
Number of pages9
JournalStem Cells Translational Medicine
Volume3
Issue number3
DOIs
StatePublished - 2014

Keywords

  • Histocompatibility
  • Imprinting
  • Parthenogenesis
  • Pluripotent stem cells

ASJC Scopus subject areas

  • General Medicine

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