Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride

Hua Zhao, Robert G. Luo, Dean Wei, Sanjay V. Malhotra

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The N-acetyl-homophenylalanine ethyl ester was synthesized by a simple three-step-reaction strategy. L-(+)-homophenylalanine hydrochloride with 98% ee was obtained through a kinetic resolution process using industrial enzyme alcalase. Compared with other methods, this strategy has the advantage of economical and simple procedure giving high product optical purity.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
Issue number1
StatePublished - Jan 2002
Externally publishedYes


  • Homophenylalanine
  • Kinetic resolution
  • Unnatural amino acids

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry


Dive into the research topics of 'Concise synthesis and enzymatic resolution of L-(+)-homophenylalanine hydrochloride'. Together they form a unique fingerprint.

Cite this