Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS

Halina Offner; Arthur A. Vandenbark

doi:10.1080/08830180500371462

Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS

Halina Offner
, Arthur A. Vandenbark

Neurology

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the FoxP3 gene and associated activity of regulatory T (Treg) cells. E2 increases the number and activity of FoxP3⁺ T cells through Esr-1 signaling during TCR activation of CD4⁺CD25^- T cells. In contrast, TCR peptide therapy appears to increase the frequency of regulatory FoxP3⁺ T cells specific for self-TCR determinants expressed by targeted pathogenic T cells. The combined effects on Treg expansion and activation induced by these distinct immunoregulatory approaches may account for their potent effects on clinical EAE and argue for a similar combined therapeutic approach for MS.

Original language	English (US)
Pages (from-to)	447-477
Number of pages	31
Journal	International reviews of immunology
Volume	24
Issue number	5-6
DOIs	https://doi.org/10.1080/08830180500371462
State	Published - Sep 2005

Funding

The authors wish to thank the many members of our laboratories who contributed to these studies, our clinical collaborators, and Ms. Eva Niehaus for assistance in preparation of the manuscript. These studies were supported by The Immune Tolerance Network, NIH grants NS23221, NS23444, NS45445, and NS49210, National MS Society grants RD3405A2 and RG3400A4, The Nancy Davis MS Center Without Walls, the Biomedical Laboratory R&D Service, Department of Veterans’ Affairs, and The Immune Response Corporation.

Funders	Funder number
Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development
The Immune Response Corporation
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	NS45445, NS23221, NS23444
National Institute of Neurological Disorders and Stroke	P01NS049210
U.S. Department of Veterans Affairs
National Multiple Sclerosis Society	RD3405A2, RG3400A4
Immune Tolerance Network

Keywords

Estrogen
Experimental autoimmune encephalomyelitis
FoxP3
Multiple sclerosis
T cell receptor
Therapy

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1080/08830180500371462

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title = "Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS",

abstract = "Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the FoxP3 gene and associated activity of regulatory T (Treg) cells. E2 increases the number and activity of FoxP3+ T cells through Esr-1 signaling during TCR activation of CD4+CD25- T cells. In contrast, TCR peptide therapy appears to increase the frequency of regulatory FoxP3+ T cells specific for self-TCR determinants expressed by targeted pathogenic T cells. The combined effects on Treg expansion and activation induced by these distinct immunoregulatory approaches may account for their potent effects on clinical EAE and argue for a similar combined therapeutic approach for MS.",

keywords = "Estrogen, Experimental autoimmune encephalomyelitis, FoxP3, Multiple sclerosis, T cell receptor, Therapy",

author = "Halina Offner and Vandenbark, \{Arthur A.\}",

note = "Funding Information: The authors wish to thank the many members of our laboratories who contributed to these studies, our clinical collaborators, and Ms. Eva Niehaus for assistance in preparation of the manuscript. These studies were supported by The Immune Tolerance Network, NIH grants NS23221, NS23444, NS45445, and NS49210, National MS Society grants RD3405A2 and RG3400A4, The Nancy Davis MS Center Without Walls, the Biomedical Laboratory R\&D Service, Department of Veterans{\textquoteright} Affairs, and The Immune Response Corporation.",

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doi = "10.1080/08830180500371462",

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N2 - Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the FoxP3 gene and associated activity of regulatory T (Treg) cells. E2 increases the number and activity of FoxP3+ T cells through Esr-1 signaling during TCR activation of CD4+CD25- T cells. In contrast, TCR peptide therapy appears to increase the frequency of regulatory FoxP3+ T cells specific for self-TCR determinants expressed by targeted pathogenic T cells. The combined effects on Treg expansion and activation induced by these distinct immunoregulatory approaches may account for their potent effects on clinical EAE and argue for a similar combined therapeutic approach for MS.

AB - Both estrogen (E2) and T-cell receptor (TCR) peptides have beneficial effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS) that involve distinct but congruent mechanisms. Of interest, these two approaches share an ability to enhance expression of the FoxP3 gene and associated activity of regulatory T (Treg) cells. E2 increases the number and activity of FoxP3+ T cells through Esr-1 signaling during TCR activation of CD4+CD25- T cells. In contrast, TCR peptide therapy appears to increase the frequency of regulatory FoxP3+ T cells specific for self-TCR determinants expressed by targeted pathogenic T cells. The combined effects on Treg expansion and activation induced by these distinct immunoregulatory approaches may account for their potent effects on clinical EAE and argue for a similar combined therapeutic approach for MS.

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KW - Multiple sclerosis

KW - T cell receptor

KW - Therapy

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ER -

Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS

Abstract

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Keywords

ASJC Scopus subject areas

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