Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W.M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer

doi:10.1167/iovs.63.2.12

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf FuchshoferPreethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W.M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer

Ophthalmology

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

Original language	English (US)
Article number	12
Journal	Investigative Ophthalmology and Visual Science
Volume	63
Issue number	2
DOIs	https://doi.org/10.1167/iovs.63.2.12
State	Published - Feb 2022

Keywords

Conventional outflow
Glaucoma
Intraocular pressure
Mouse model
Ocular hypertension
Outflow facility

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Access to Document

10.1167/iovs.63.2.12

Cite this

McDowell, C. M., Kizhatil, K., Elliott, M. H., Overby, D. R., van Batenburg-Sherwood, J., Cameron Millar, J., Kuehn, M. H., Zode, G., Acott, T. S., Anderson, M. G., Bhattacharya, S. K., Bertrand, J. A., Borras, T., Bovenkamp, D. E., Cheng, L., Danias, J., De Ieso, M. L., Du, Y., Faralli, J. A., ... Daniel Stamer, W. (2022). Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. Investigative Ophthalmology and Visual Science, 63(2), Article 12. https://doi.org/10.1167/iovs.63.2.12

McDowell, CM, Kizhatil, K, Elliott, MH, Overby, DR, van Batenburg-Sherwood, J, Cameron Millar, J, Kuehn, MH, Zode, G, Acott, TS, Anderson, MG, Bhattacharya, SK, Bertrand, JA, Borras, T, Bovenkamp, DE, Cheng, L, Danias, J, De Ieso, ML, Du, Y, Faralli, JA, Fuchshofer, R, Ganapathy, PS, Gong, H, Herberg, S, Hernandez, H, Humphries, P, John, SWM, Kaufman, PL, Keller, KE , Kelley, MJ, Kelly, RA, Krizaj, D, Kumar, A, Leonard, BC, Lieberman, RL, Liton, P, Liu, Y, Liu, KC, Lopez, NN, Mao, W, Mavlyutov, T, McDonnell, F, McLellan, GJ, Mzyk, P, Nartey, A, Pasquale, LR, Patel, GC, Pattabiraman, PP, Peters, DM, Raghunathan, V, Rao, PV, Rayana, N, Raychaudhuri, U, Reina-Torres, E, Ren, R, Rhee, D, Chowdhury, UR, Samples, JR, Griffen Samples, E, Sharif, N, Schuman, JS, Sheffield, VC, Stevenson, CH, Soundararajan, A, Subramanian, P, Sugali, CK, Sun, Y, Toris, CB, Torrejon, KY, Vahabikashi, A, Vranka, JA, Wang, T, Willoughby, CE, Xin, C, Yun, H, Zhang, HF, Fautsch, MP, Tamm, ER, Clark, AF, Ross Ethier, C & Daniel Stamer, W 2022, 'Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms', Investigative Ophthalmology and Visual Science, vol. 63, no. 2, 12. https://doi.org/10.1167/iovs.63.2.12

@article{69a73802062249f68cedb8186d2cd61d,

title = "Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms",

abstract = "Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.",

keywords = "Conventional outflow, Glaucoma, Intraocular pressure, Mouse model, Ocular hypertension, Outflow facility",

author = "McDowell, {Colleen M.} and Krishnakumar Kizhatil and Elliott, {Michael H.} and Overby, {Darryl R.} and {van Batenburg-Sherwood}, Joseph and {Cameron Millar}, J. and Kuehn, {Markus H.} and Gulab Zode and Acott, {Ted S.} and Anderson, {Michael G.} and Bhattacharya, {Sanjoy K.} and Bertrand, {Jacques A.} and Terete Borras and Bovenkamp, {Diane E.} and Lin Cheng and John Danias and {De Ieso}, {Michael Lucio} and Yiqin Du and Faralli, {Jennifer A.} and Rudolf Fuchshofer and Ganapathy, {Preethi S.} and Haiyan Gong and Samuel Herberg and Humberto Hernandez and Peter Humphries and John, {Simon W.M.} and Kaufman, {Paul L.} and Keller, {Kate E.} and Kelley, {Mary J.} and Kelly, {Ruth A.} and David Krizaj and Ajay Kumar and Leonard, {Brian C.} and Lieberman, {Raquel L.} and Paloma Liton and Yutao Liu and Liu, {Katy C.} and Lopez, {Navita N.} and Weiming Mao and Timur Mavlyutov and Fiona McDonnell and McLellan, {Gillian J.} and Philip Mzyk and Andrews Nartey and Pasquale, {Louis R.} and Patel, {Gaurang C.} and Pattabiraman, {Padmanabhan P.} and Peters, {Donna M.} and Vijaykrishna Raghunathan and Rao, {Ponugoti Vasantha} and Naga Rayana and Urmimala Raychaudhuri and Ester Reina-Torres and Ruiyi Ren and Douglas Rhee and Chowdhury, {Uttio Roy} and Samples, {John R.} and {Griffen Samples}, E. and Najam Sharif and Schuman, {Joel S.} and Sheffield, {Val C.} and Stevenson, {Cooper H.} and Avinash Soundararajan and Preeti Subramanian and Sugali, {Chenna Kesavulu} and Yang Sun and Toris, {Carol B.} and Torrejon, {Karen Y.} and Amir Vahabikashi and Vranka, {Janice A.} and Ting Wang and Willoughby, {Colin E.} and Chen Xin and Hongmin Yun and Zhang, {Hao F.} and Fautsch, {Michael P.} and Tamm, {Ernst R.} and Clark, {Abbot F.} and {Ross Ethier}, C. and {Daniel Stamer}, W.",

year = "2022",

month = feb,

doi = "10.1167/iovs.63.2.12",

language = "English (US)",

volume = "63",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "2",

}

TY - JOUR

T1 - Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

AU - McDowell, Colleen M.

AU - Kizhatil, Krishnakumar

AU - Elliott, Michael H.

AU - Overby, Darryl R.

AU - van Batenburg-Sherwood, Joseph

AU - Cameron Millar, J.

AU - Kuehn, Markus H.

AU - Zode, Gulab

AU - Acott, Ted S.

AU - Anderson, Michael G.

AU - Bhattacharya, Sanjoy K.

AU - Bertrand, Jacques A.

AU - Borras, Terete

AU - Bovenkamp, Diane E.

AU - Cheng, Lin

AU - Danias, John

AU - De Ieso, Michael Lucio

AU - Du, Yiqin

AU - Faralli, Jennifer A.

AU - Fuchshofer, Rudolf

AU - Ganapathy, Preethi S.

AU - Gong, Haiyan

AU - Herberg, Samuel

AU - Hernandez, Humberto

AU - Humphries, Peter

AU - John, Simon W.M.

AU - Kaufman, Paul L.

AU - Keller, Kate E.

AU - Kelley, Mary J.

AU - Kelly, Ruth A.

AU - Krizaj, David

AU - Kumar, Ajay

AU - Leonard, Brian C.

AU - Lieberman, Raquel L.

AU - Liton, Paloma

AU - Liu, Yutao

AU - Liu, Katy C.

AU - Lopez, Navita N.

AU - Mao, Weiming

AU - Mavlyutov, Timur

AU - McDonnell, Fiona

AU - McLellan, Gillian J.

AU - Mzyk, Philip

AU - Nartey, Andrews

AU - Pasquale, Louis R.

AU - Patel, Gaurang C.

AU - Pattabiraman, Padmanabhan P.

AU - Peters, Donna M.

AU - Raghunathan, Vijaykrishna

AU - Rao, Ponugoti Vasantha

AU - Rayana, Naga

AU - Raychaudhuri, Urmimala

AU - Reina-Torres, Ester

AU - Ren, Ruiyi

AU - Rhee, Douglas

AU - Chowdhury, Uttio Roy

AU - Samples, John R.

AU - Griffen Samples, E.

AU - Sharif, Najam

AU - Schuman, Joel S.

AU - Sheffield, Val C.

AU - Stevenson, Cooper H.

AU - Soundararajan, Avinash

AU - Subramanian, Preeti

AU - Sugali, Chenna Kesavulu

AU - Sun, Yang

AU - Toris, Carol B.

AU - Torrejon, Karen Y.

AU - Vahabikashi, Amir

AU - Vranka, Janice A.

AU - Wang, Ting

AU - Willoughby, Colin E.

AU - Xin, Chen

AU - Yun, Hongmin

AU - Zhang, Hao F.

AU - Fautsch, Michael P.

AU - Tamm, Ernst R.

AU - Clark, Abbot F.

AU - Ross Ethier, C.

AU - Daniel Stamer, W.

PY - 2022/2

Y1 - 2022/2

N2 - Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

AB - Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.

KW - Conventional outflow

KW - Glaucoma

KW - Intraocular pressure

KW - Mouse model

KW - Ocular hypertension

KW - Outflow facility

UR - http://www.scopus.com/inward/record.url?scp=85124219559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85124219559&partnerID=8YFLogxK

U2 - 10.1167/iovs.63.2.12

DO - 10.1167/iovs.63.2.12

M3 - Article

C2 - 35129590

AN - SCOPUS:85124219559

SN - 0146-0404

VL - 63

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 2

M1 - 12

ER -

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this