Contemporaneous Risk Factors for Visual Acuity in Non-Infectious Uveitis

Maxwell Pistilli, Sapna S. Gangaputra, Siddharth S. Pujari, Douglas A. Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, James T. Rosenbaum, H. Nida Sen, Eric B. Suhler, Jennifer E. Thorne, Nirali P. Bhatt, C. Stephen Foster, Hosne Begum, Tonetta D. Fitzgerald, Kurt A. Dreger, John H. Kempen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Introduction: We evaluated the associations of clinical and demographic characteristics with visual acuity (VA) with over 5 years in a subspecialty noninfectious uveitis population. Methods: Retrospective data from 5,530 noninfectious uveitis patients were abstracted by expert reviewers, and contemporaneous associations of VA with demographic and clinical factors were modeled. Results: Patients were a median of 41 years old, 65% female, and 73% white. Eyes diagnosed ≥5 years prior to cohort entry had worse VA (−1.2 lines) than those diagnosed <6 months prior, and eyes with cataract surgery performed prior to entry had worse VA (−5.9 lines) than those performed during follow-up. Vitreous haze (−4.2 lines for 3+ vs quiet), hypotony (−2.5 lines for ≤5 mm Hg vs 6–23 mm Hg), and CNV (−1.8 lines) all were strongly associated with reduced VA. Conclusion: Factors associated with reduced VA included well-known structural complications, and lack of subspecialty care during cataract surgery.

Original languageEnglish (US)
Pages (from-to)1056-1063
Number of pages8
JournalOcular Immunology and Inflammation
Issue number6
StatePublished - 2021


  • Visual Acuity
  • risk Factors
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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