TY - JOUR
T1 - Control of firing patterns through modulation of axon initial segment T-type calcium channels
AU - Bender, Kevin J.
AU - Uebele, Victor N.
AU - Renger, John J.
AU - Trussell, Laurence O.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/1
Y1 - 2012/1
N2 - Spontaneously active neurons typically fire either in a regular pattern or in bursts. While much is known about the subcellular location and biophysical properties of conductances that underlie regular spontaneous activity, less is known about those that underlie bursts. Here, we show that T-type Ca 2+ channels localized to the site of action potential initiation in the axon initial segment play a pivotal role in spontaneous burst generation. In auditory brainstem interneurons, axon initial segment Ca 2+ influx is selectively downregulated by dopaminergic signalling. This regulation has marked effects on spontaneous activity, converting the predominant mode of spontaneous activity from bursts to regular spiking. Thus, the axon initial segment is a key site, and dopamine a key regulator, of spontaneous bursting activity.
AB - Spontaneously active neurons typically fire either in a regular pattern or in bursts. While much is known about the subcellular location and biophysical properties of conductances that underlie regular spontaneous activity, less is known about those that underlie bursts. Here, we show that T-type Ca 2+ channels localized to the site of action potential initiation in the axon initial segment play a pivotal role in spontaneous burst generation. In auditory brainstem interneurons, axon initial segment Ca 2+ influx is selectively downregulated by dopaminergic signalling. This regulation has marked effects on spontaneous activity, converting the predominant mode of spontaneous activity from bursts to regular spiking. Thus, the axon initial segment is a key site, and dopamine a key regulator, of spontaneous bursting activity.
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U2 - 10.1113/jphysiol.2011.218768
DO - 10.1113/jphysiol.2011.218768
M3 - Article
C2 - 22063631
AN - SCOPUS:84855180863
SN - 0022-3751
VL - 590
SP - 109
EP - 118
JO - Journal of Physiology
JF - Journal of Physiology
IS - 1
ER -