Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis

Jack P. Rock; Edward H. Oldfield; Heinrich M. Schulte; Phillip W. Gold; Paul L. Kornblith; Lynn Loriaux; George P. Chrousos

doi:10.1016/0006-8993(84)90315-9

Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis

Jack P. Rock, Edward H. Oldfield, Heinrich M. Schulte, Phillip W. Gold, Paul L. Kornblith, Lynn Loriaux, George P. Chrousos

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 μg/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of this releasing factor and occurred without elevation of plasma concentrations of CRF, measured by radioimmunoassay. Thus, the cerebrospinal fluid (CSF) can serve as a conduit for delivery of CRF to the pituitary gland.

Original language	English (US)
Pages (from-to)	365-368
Number of pages	4
Journal	Brain research
Volume	323
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90315-9
State	Published - Dec 10 1984
Externally published	Yes

Keywords

ACTH
cerebrospinal fluid
corticotropin releasing factor
cortisol
tanycytes

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90315-9

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title = "Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis",

abstract = "Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 μg/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of this releasing factor and occurred without elevation of plasma concentrations of CRF, measured by radioimmunoassay. Thus, the cerebrospinal fluid (CSF) can serve as a conduit for delivery of CRF to the pituitary gland.",

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T1 - Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis

AU - Rock, Jack P.

AU - Oldfield, Edward H.

AU - Schulte, Heinrich M.

AU - Gold, Phillip W.

AU - Kornblith, Paul L.

AU - Loriaux, Lynn

AU - Chrousos, George P.

PY - 1984/12/10

Y1 - 1984/12/10

N2 - Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 μg/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of this releasing factor and occurred without elevation of plasma concentrations of CRF, measured by radioimmunoassay. Thus, the cerebrospinal fluid (CSF) can serve as a conduit for delivery of CRF to the pituitary gland.

AB - Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 μg/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of this releasing factor and occurred without elevation of plasma concentrations of CRF, measured by radioimmunoassay. Thus, the cerebrospinal fluid (CSF) can serve as a conduit for delivery of CRF to the pituitary gland.

KW - ACTH

KW - cerebrospinal fluid

KW - corticotropin releasing factor

KW - cortisol

KW - tanycytes

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Corticotropin releasing factor administered into the ventricular CSF stimulates the pituitary-adrenal axis

Abstract

Keywords

ASJC Scopus subject areas

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