TY - JOUR
T1 - Coxsackievirus A24 causing acute conjunctivitis in a 2023 outbreak in Vietnam
AU - SCORPIO Study Group
AU - Tran, Huy
AU - Ha, Thao
AU - Hoang, Linh
AU - Tran, Yen
AU - Ruder, Kevin
AU - Zhong, Lina
AU - Chen, Cindi
AU - Liu, Yu Heng
AU - Yu, Danny
AU - Abraham, Thomas
AU - Hinterwirth, Armin
AU - Deiner, Michael
AU - Porco, Travis C.
AU - Lietman, Thomas M.
AU - Doan, Thuy
AU - Seitzman, Gerami D.
AU - Prajna, Lalitha
AU - Prajna, N. Venkatesh
AU - Gunasekaran, Ramesh
AU - Sharma, Sankalp Singh
AU - Teja, Vishnu
AU - Chaudhary, Meenu
AU - Sitaula, Sanjeeta
AU - Sié, Ali
AU - Coulibaly, Boubacar
AU - Bountogo, Mamadou
AU - Somkijrungroj, Thanapong
AU - Satitpitakul, Vannarut
AU - Mai, Linh Hoàng
AU - Xuân, Thảo Hạ
AU - Urzua, Cristhian A.
AU - Vega, Fabian
AU - Salgado, Felipe
AU - Cuitino, Loreto
AU - Pérez, Fernando Pérez
AU - Martínez, Jaime Macías
AU - Lansingh, Van Charles
AU - Thanapaisal, Sukhumal
AU - Laovirojjanakul, Wipada
AU - McKie, George
AU - Chavez, Kenia
AU - Redd, Travis
AU - Chamberlain, Winston
AU - Cheng, Angel
AU - Tham, Vivien
AU - Sansanayudh, Wiwan
AU - Yakoura, Abba Kaka Hajia
AU - Amza, Abdou
AU - Souley, Abdoul Salam Youssoufou
AU - Diori, Adam Nouhou
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/9
Y1 - 2024/9
N2 - Objectives: To determine the associated pathogen during the 2023 conjunctivitis outbreak in Vietnam Methods: RNA-sequencing was used to identify pathogens before and during the outbreak. Results: 24 patients with infectious conjunctivitis between March and October 2023 from Hai Yen Vision Institute in Vietnam were swabbed. Coxsackievirus A24v was the most common pathogen identified. Phylogenetic analysis of these strains demonstrates similarities to the Coxsackievirus identified in the 2022 India outbreak. Human adenovirus D was also circulating. Ocular findings of tearing, purulence, and itching were common in this outbreak. Conclusions: Multiple viruses can co-circulate during conjunctivitis outbreaks. Hemorrhagic conjunctivitis, commonly associated with coxsackievirus conjunctivitis, was not a common clinical sign in this outbreak. Repeat genetic surveillance, with the notable inclusion of RNA virus detection strategies, is important for outbreak detection.
AB - Objectives: To determine the associated pathogen during the 2023 conjunctivitis outbreak in Vietnam Methods: RNA-sequencing was used to identify pathogens before and during the outbreak. Results: 24 patients with infectious conjunctivitis between March and October 2023 from Hai Yen Vision Institute in Vietnam were swabbed. Coxsackievirus A24v was the most common pathogen identified. Phylogenetic analysis of these strains demonstrates similarities to the Coxsackievirus identified in the 2022 India outbreak. Human adenovirus D was also circulating. Ocular findings of tearing, purulence, and itching were common in this outbreak. Conclusions: Multiple viruses can co-circulate during conjunctivitis outbreaks. Hemorrhagic conjunctivitis, commonly associated with coxsackievirus conjunctivitis, was not a common clinical sign in this outbreak. Repeat genetic surveillance, with the notable inclusion of RNA virus detection strategies, is important for outbreak detection.
KW - Conjunctivitis
KW - Coxsackievirus
KW - Epidemic
KW - Keratoconjunctivitis (EKC)
KW - Vietnam
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U2 - 10.1016/j.ijid.2024.107133
DO - 10.1016/j.ijid.2024.107133
M3 - Article
C2 - 38876162
AN - SCOPUS:85197514365
SN - 1201-9712
VL - 146
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
M1 - 107133
ER -