Cranial dystonia: Double-blind crossover study of anticholinergics

John G. Nutt, John P. Hammerstad, Pat deGarmo, Julie Carter

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishable in the other eight patients except for the higher incidence of central and peripheral anticholinergic side effects with trihexyphenidyl.

Original languageEnglish (US)
Pages (from-to)215-517
Number of pages303
Issue number2
StatePublished - Feb 1984

ASJC Scopus subject areas

  • Clinical Neurology


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