Craniofacial manifestations of β-thalassemia major

Bahram Javid, Nasser Said-Al-Naief

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Hemoglobinopathies are by far the most common genetic diseases, affecting millions worldwide with a prevalence for natives of Iran, Southeast Asia, and the Caspian Sea, as part of the so-called Thalassemia Belt, and an overall incidence ranging approximately from 3 to 100 patients per 100,000 population. β-Thalassemia major is of particular significance, providing bad outcomes despite aggressive therapeutic approaches. We report a case of β-thalassemia in a 5-year-old Persian boy who presented with classical diagnostic features of the disease and who did not survive despite an aggressive management approach. A review of the clinical, radiographic, laboratory, and therapeutic characteristics as well as diagnostic tests of this disease is also presented. The multifactorial challenges that face clinicians in the management of this serious disease are also reviewed.

Original languageEnglish (US)
Pages (from-to)e33-e40
JournalOral surgery, oral medicine, oral pathology and oral radiology
Issue number1
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Pathology and Forensic Medicine
  • Dentistry (miscellaneous)
  • Radiology Nuclear Medicine and imaging


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