Critical Care Nutrition: Where's the Evidence?

Jayshil J. Patel, Ryan T. Hurt, Stephen A. McClave, Robert G. Martindale

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


The surgical critically ill patient is subject to a variable and complex metabolic response, which has detrimental effects on immunity, wound healing, and preservation of lean body muscle. The concept of nutrition support has evolved into nutrition therapy, whereby the primary objectives are to prevent oxidative cell injury, modulate the immune response, and attenuate the metabolic response. This review outlines the metabolic response to critical illness, describes nutritional risk; reviews the evidence for the role, dose, and timing of enteral and parenteral nutrition, and reviews the evidence for immunonutrition in the surgical intensive care unit.

Original languageEnglish (US)
Pages (from-to)397-412
Number of pages16
JournalCritical Care Clinics
Issue number2
StatePublished - Apr 1 2017


  • Critical care nutrition
  • Enteral nutrition
  • Metabolic stress response
  • Nutritional risk
  • Parenteral nutrition
  • Permissive underfeeding
  • Supplemental parenteral nutrition
  • Trophic feeding

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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