Cryosurgery for Malignancies of the Eyelid

F. T. Fraunfelder, S. A. Zacarian, B. L. Limmer, D. Wingfield

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The results of liquid nitrogen spray technique for 310 biopsy-proven eyelid malignancies are reviewed. The raw recurrence rate for basal cell carcinomas of the eyelids with a mean follow-up of almost three years is 4.2%, while the recurrence rate is 6% in 49 cases followed for five years. For all lid malignancies 10 mm or less in diameter, a 2.0% raw recurrence rate was obtained; however, in those lesions larger than 10 mm, this rose to 9.5%. With this form of therapy, basal cell carcinomas with infiltrative, nonelevated, indistinct borders had twice the recurrence rate than those tumors with elevated distinct borders. Twenty-one squamous cell carcinomas treated with cryosurgery with an average follow-up of 21.6 months have yet to show a recurrence. Complications with cryosurgery include permanent loss of eyelashes and depigmentation lasting from six months to over six years. Depending on the extent and location of the tumor, eyelid defects occurred. To date, five plastic reconstructive procedures have been required for ectropion or lid defects; however, no lacrimal outflow surgery has as yet been required.

Original languageEnglish (US)
Pages (from-to)461-465
Number of pages5
Issue number6
StatePublished - 1980
Externally publishedYes


  • basal cell carcinollla
  • carcinoma
  • cryosurgery
  • cryotherapy
  • eyelid malignancies
  • liquid nitrogen
  • squamous cell

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Cryosurgery for Malignancies of the Eyelid'. Together they form a unique fingerprint.

Cite this