TY - JOUR
T1 - Culture-proven endophthalmitis after intravitreal injection
T2 - A 10-year analysis
AU - Simonett, Joseph M.
AU - Igelman, Austin
AU - Taylor, Stanford C.
AU - Peter, J. C.
AU - Hwang, Thomas S.
AU - Lin, Phoebe
AU - Lauer, Andreas K.
AU - Flaxel, Christina J.
N1 - Funding Information:
Originally submitted May 25, 2018. Revision received September 30, 2018. Accepted for publication November 2, 2018. This project was supported by core grant P30 EY010572 (Casey Eye Institute) from the National Institutes of Health (Bethesda, MD) and an unrestricted grant to the Casey Eye Institute from Research to Prevent Blindness (New York, NY). Dr. Campbell has received personal fees from Allergan outside the submitted work. The remaining authors report no relevant financial disclosures. Address correspondence to Christina J. Flaxel, MD, Casey Eye Institute, Oregon Health & Science University, 3303 SW Bond Ave., Center for Health and Healing Building 1, 11th Floor, Portland, OR 97239; email: flaxelc@ohsu.edu. doi: 10.3928/23258160-20181212-05
Publisher Copyright:
© 2019 Slack Incorporated. All rights reserved.
PY - 2019/1
Y1 - 2019/1
N2 - BACKGROUND AND OBJECTIVE: To report on the microbiology, management, and visual outcomes of intravitreal injection (IVI)-Associated, culture-proven endophthalmitis. PATIENTS AND METHODS: All patients seen at a tertiary referral center with culture-proven endophthalmitis associated with an IVI between June 2007 and July 2017 were included in this retrospective analysis. RESULTS: Thirty-five patients with culture-positive endophthalmitis following IVI were identified. All gram-positive organisms (34 of 35) were susceptible to vancomycin. Cases due to pathogens associated with oral or respiratory flora were common (31.4%, n = 11), presented earlier (2.0 days vs. 4.6 days, P < .001), were more likely to undergo pars plana vitrectomy (81.8% vs. 25.0%, P = .002) and had worse visual acuity outcomes. CONCLUSION: IVI-Associated endophthalmitis pathogens and anti-microbial susceptibilities in the Pacific Northwest are similar to those reported from other geographic locations. Bacteria associated with the oral and respiratory flora are common isolates that result in a more aggressive course and worse visual outcomes.
AB - BACKGROUND AND OBJECTIVE: To report on the microbiology, management, and visual outcomes of intravitreal injection (IVI)-Associated, culture-proven endophthalmitis. PATIENTS AND METHODS: All patients seen at a tertiary referral center with culture-proven endophthalmitis associated with an IVI between June 2007 and July 2017 were included in this retrospective analysis. RESULTS: Thirty-five patients with culture-positive endophthalmitis following IVI were identified. All gram-positive organisms (34 of 35) were susceptible to vancomycin. Cases due to pathogens associated with oral or respiratory flora were common (31.4%, n = 11), presented earlier (2.0 days vs. 4.6 days, P < .001), were more likely to undergo pars plana vitrectomy (81.8% vs. 25.0%, P = .002) and had worse visual acuity outcomes. CONCLUSION: IVI-Associated endophthalmitis pathogens and anti-microbial susceptibilities in the Pacific Northwest are similar to those reported from other geographic locations. Bacteria associated with the oral and respiratory flora are common isolates that result in a more aggressive course and worse visual outcomes.
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U2 - 10.3928/23258160-20181212-05
DO - 10.3928/23258160-20181212-05
M3 - Article
C2 - 30640393
AN - SCOPUS:85059889622
SN - 2325-8160
VL - 50
SP - 33
EP - 38
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
IS - 1
ER -