TY - JOUR
T1 - Cutaneous Plasmacytosis and Idiopathic Multicentric Castleman Disease
T2 - A Spectrum of Disease?
AU - Drissi, Madeeha
AU - Dunlap, Rachel
AU - Clayton, Lara
AU - Raess, Philipp W.
AU - Mengden Koon, Stephanie
AU - White, Kevin
N1 - Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Cutaneous/systemic plasmacytosis (C/SP) is a plasma cell disorder characterized by reddish-brown patches, lymphadenopathy, and hypergammaglobulinemia. The degree to which C/SP overlaps with other plasma cell proliferative disorders and neoplasms is incompletely understood. We present the case of a patient with a several-year history of cutaneous plasmacytosis and evidence of systemic involvement with concurrent idiopathic multicentric Castleman disease (iMCD) involving a lymph node. There have been only a few reports of systemic iMCD preceded by a long, asymptomatic phase of cutaneous manifestations. We discuss the relationship between C/SP and iMCD and elaborate on the pathophysiological overlap of these 2 conditions and potential similarities in their pathogenesis. We suggest that the 2 diseases may represent the same entity presenting on a spectrum, with individuals diagnosed with C/SP at risk for progression to iMCD.
AB - Cutaneous/systemic plasmacytosis (C/SP) is a plasma cell disorder characterized by reddish-brown patches, lymphadenopathy, and hypergammaglobulinemia. The degree to which C/SP overlaps with other plasma cell proliferative disorders and neoplasms is incompletely understood. We present the case of a patient with a several-year history of cutaneous plasmacytosis and evidence of systemic involvement with concurrent idiopathic multicentric Castleman disease (iMCD) involving a lymph node. There have been only a few reports of systemic iMCD preceded by a long, asymptomatic phase of cutaneous manifestations. We discuss the relationship between C/SP and iMCD and elaborate on the pathophysiological overlap of these 2 conditions and potential similarities in their pathogenesis. We suggest that the 2 diseases may represent the same entity presenting on a spectrum, with individuals diagnosed with C/SP at risk for progression to iMCD.
KW - cutaneous plasmacytosis, systemic plasmacytosis, idiopathic multicentric Castleman's disease, multicentric plasmacytic castleman's disease, multicentric Castleman's Disease, HHV-8
UR - http://www.scopus.com/inward/record.url?scp=85126490846&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126490846&partnerID=8YFLogxK
U2 - 10.1097/DAD.0000000000002109
DO - 10.1097/DAD.0000000000002109
M3 - Article
C2 - 34966045
AN - SCOPUS:85126490846
SN - 0193-1091
VL - 44
SP - 294
EP - 296
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 4
ER -