TY - JOUR
T1 - Cutaneous Reactions to Chemotherapy
T2 - Commonly Seen, Less Described, Little Understood
AU - Sanborn, Rachel E.
AU - Sauer, David A.
PY - 2008/1
Y1 - 2008/1
N2 - Chemotherapeutic and molecularly targeted agents are associated with a wide array of cutaneous toxicities. Despite the variety of toxicities, surprisingly little is understood regarding the pathogenesis underlying these reactions. This article reviews the most common cutaneous toxicities of cytotoxic chemotherapy and molecularly targeted systemic therapy, including extravasation of chemotherapy, with a discussion of the known and postulated underlying mechanisms of action. The need for developing a greater understanding of the basis of these reactions through more detailed study is evident.
AB - Chemotherapeutic and molecularly targeted agents are associated with a wide array of cutaneous toxicities. Despite the variety of toxicities, surprisingly little is understood regarding the pathogenesis underlying these reactions. This article reviews the most common cutaneous toxicities of cytotoxic chemotherapy and molecularly targeted systemic therapy, including extravasation of chemotherapy, with a discussion of the known and postulated underlying mechanisms of action. The need for developing a greater understanding of the basis of these reactions through more detailed study is evident.
UR - http://www.scopus.com/inward/record.url?scp=36048990863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048990863&partnerID=8YFLogxK
U2 - 10.1016/j.det.2007.08.006
DO - 10.1016/j.det.2007.08.006
M3 - Review article
C2 - 18023774
AN - SCOPUS:36048990863
SN - 0733-8635
VL - 26
SP - 103
EP - 119
JO - Dermatologic Clinics
JF - Dermatologic Clinics
IS - 1
ER -