@article{5c724a288cd5421cad22c78238756bb9,
title = "CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles",
abstract = "During unresolved infections, some viruses escape immunological control and establish a persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which persists in follicular helper T cells (TFH cells), and Epstein-Barr virus (EBV), which persists in B cells. Here we identified a specialized group of cytotoxic T cells (TC cells) that expressed the chemokine receptor CXCR5, selectively entered B cell follicles and eradicated infected TFH cells and B cells. The differentiation of these cells, which we have called 'follicular cytotoxic T cells' (TFCcells), required the transcription factors Bcl6, E2A and TCF-1 but was inhibited by the transcriptional regulators Blimp1, Id2 and Id3. Blimp1 and E2A directly regulated Cxcr5 expression and, together with Bcl6 and TCF-1, formed a transcriptional circuit that guided TFCcell development. The identification of TFCcells has far-reaching implications for the development of strategies to control infections that target B cells and TFH cells and to treat B cell-derived malignancies.",
author = "Leong, {Yew Ann} and Yaping Chen and Ong, {Hong Sheng} and Di Wu and Kevin Man and Claire Deleage and Martina Minnich and Meckiff, {Benjamin J.} and Yunbo Wei and Zhaohua Hou and Dimitra Zotos and Fenix, {Kevin A.} and Anurag Atnerkar and Simon Preston and Chipman, {Jeffrey G.} and Beilman, {Greg J.} and Allison, {Cody C.} and Lei Sun and Peng Wang and Jiawei Xu and Toe, {Jesse G.} and Lu, {Hao K.} and Yong Tao and Umaimainthan Palendira and Dent, {Alexander L.} and Landay, {Alan L.} and Marc Pellegrini and Iain Comerford and McColl, {Shaun R.} and Schacker, {Timothy W.} and Long, {Heather M.} and Estes, {Jacob D.} and Meinrad Busslinger and Belz, {Gabrielle T.} and Lewin, {Sharon R.} and Axel Kallies and Di Yu",
note = "Funding Information: Supported by the National Health and Medical Research Council of Australia (Y.A.L. and S.R.L.; GNT1085509 to D.Y.; and GNT1085151 to A.K.), Monash University (D.Y.), the amfAR Research Consortium on HIV Eradication (109327-59-RGRL, D.Y., S.R.L. and A.L.L.), The Creative and Novel Ideas in HIV Research Program of The International AIDS Society (D.Y.), Australian Centre for HIV and Hepatitis Virology Research (2015-69 to D.Y.), The Priority Research Program of Shandong Academy of Sciences (D.Y.), Shandong Province Taishan Scholar Program (D.Y.), the Sylvia and Charles Viertel Foundation (A.K.), the Delaney AIDS Research Enterprise to find a cure, Martin Delaney Collaboratories, the National Institute for Allergy and Infectious Diseases of the US National Institutes of Health (U19 AI096109 to S.R.L., T.W.S. and J.D.E.), Bloodwise, UK (15021 to H.M.L. and B.J.M.), the National Cancer Institute of the US National Institutes of Health (HHSN261200800001E), and the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Publisher Copyright: {\textcopyright} 2016 Nature America, Inc. All rights reserved.",
year = "2016",
month = sep,
day = "20",
doi = "10.1038/ni.3543",
language = "English (US)",
volume = "17",
pages = "1187--1196",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "10",
}