Cyclic AMP, a nonessential regulator of the cell cycle

P. Coffino, J. W. Gray, G. M. Tomkins

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Flow microfluorimetric analysis has been carried out on populations of exponentially growing S49 mouse lymphoma cells treated with dibutyryl cyclic AMP. The drug produces a specific concentration dependent block in the G1 phase of the cell cycle while other phases of the cycle are not perceptibly altered. The cell cycle of a line of mutant cells lacking the cyclic AMP dependent protein kinase is not affected by the drug. Since these mutant cells have been shown to maintain a normal cell cycle, even in the presence of high levels of cyclic AMP, periodic fluctuations in the levels of the cyclic nucleotide cannot be required for or determine progression through the cell cycle.

Original languageEnglish (US)
Pages (from-to)878-882
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number3
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • General


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