CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms

Medicine & Life Sciences

• N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide 100%
• Janus Kinase 2 72%
• Janus Kinase Inhibitors 72%
• Cytokines 31%
• Neoplasms 16%
• 2-aminopyrimidine 13%
• 2-tyrosine 11%
• TYK2 Kinase 11%
• Alleles 10%
• Primary Myelofibrosis 9%
• Withholding Treatment 8%
• Cell Line 8%
• Drug Combinations 7%
• Hematocrit 7%
• Spleen 5%
• Phosphotransferases 5%
• Cell Count 5%
• Clinical Trials 4%
• Apoptosis 4%
• Growth 3%

Chemical Compounds

• Aminopyrimidine 38%
• Hematocrit 35%
• Phosphotransferase Inhibitor 32%
• Tyrosine 23%
• Reduction 23%
• White 21%
• Drug 13%
• Molecule 8%