TY - JOUR
T1 - Cytogenetics of uterine sarcomas
T2 - Presentation of eight new cases and review of the literature
AU - Iliszko, Mariola
AU - Mandahl, Nils
AU - Mrózek, Krzysztof
AU - Denis, Andrzej
AU - Pandis, Nikos
AU - Pejovic, Tania
AU - Babińska, Malgorzata S.
AU - Nedoszytko, Boguslaw S.
AU - Debniak, Jaroslaw S.
AU - Emerich, Janusz
AU - Hrabowska, Maria
AU - Bloomfield, Clara D.
AU - Limon, Janusz
N1 - Funding Information:
1This work was supported by Grant 4.PO5A.079.10 from the Polish State Committee for Scientific Research, the Swedish Cancer Society, and the Coleman Leukemia Research Fund.
PY - 1998/11
Y1 - 1998/11
N2 - Tissue from 14 uterine tumor samples from eight patients-four with endometrial stromal sarcoma (ESS), two with leiomyosarcoma (ULMS), and two with malignant mixed mesodermal tumor (MMMT)-were investigated cytogenetically after short-term culturing. Clonal chromosome aberrations were found in 12 tumors. One ESS showed a recombination between 7p14 and 17q12, a rearrangement characterizing a subset of ESSs. In our series, chromosomes 1, 6, 7, and 16 were involved in structural aberrations most frequently (four cases each). Net loss of 6q material was found in four cases and bands 11q13, 16q13, and 22q13 were each rearranged in four cases. Among 43 uterine sarcomas, including 12 MMTs, now available for evaluation, some differences in breakpoint distribution among different tumor types were found. Rearrangements of bands 1p32, 3p24, and 10q22 were found exclusively in ULMS, whereas aberrations of bands 6p21, 7p21, and 17q12 were found predominantly in ESS.
AB - Tissue from 14 uterine tumor samples from eight patients-four with endometrial stromal sarcoma (ESS), two with leiomyosarcoma (ULMS), and two with malignant mixed mesodermal tumor (MMMT)-were investigated cytogenetically after short-term culturing. Clonal chromosome aberrations were found in 12 tumors. One ESS showed a recombination between 7p14 and 17q12, a rearrangement characterizing a subset of ESSs. In our series, chromosomes 1, 6, 7, and 16 were involved in structural aberrations most frequently (four cases each). Net loss of 6q material was found in four cases and bands 11q13, 16q13, and 22q13 were each rearranged in four cases. Among 43 uterine sarcomas, including 12 MMTs, now available for evaluation, some differences in breakpoint distribution among different tumor types were found. Rearrangements of bands 1p32, 3p24, and 10q22 were found exclusively in ULMS, whereas aberrations of bands 6p21, 7p21, and 17q12 were found predominantly in ESS.
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U2 - 10.1006/gyno.1998.5165
DO - 10.1006/gyno.1998.5165
M3 - Article
C2 - 9826456
AN - SCOPUS:0032211924
SN - 0090-8258
VL - 71
SP - 172
EP - 176
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 2
ER -