Abstract
Rhesus macaques experimentally infected with Simian Immunodeficiency Virus (SIV) experience immunosuppression and often opportunistic infection. Among the most common opportunistic infections are rhesus cytomegalovirus (RhCMV), a ubiquitous betaherpesvirus that undergoes continuous low-level replication in immunocompetent monkeys. Upon SIV-mediated immunodeficiency, RhCMV reactivates and results in lesions in numerous organ systems including the nervous and reproductive systems. We report the first case of cytomegaloviral hypophysitis in a SIV-immunocompromised rhesus macaque.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 364-367 |
| Number of pages | 4 |
| Journal | Journal of medical primatology |
| Volume | 46 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2017 |
Funding
This work was supported by NIAID grant R01 AI117862 and used resources that were supported by the Southwest National Primate Research Center grant P51 OD011133 from the Office of Research Infrastructure Programs, National Institutes of Health.
| Funders | Funder number |
|---|---|
| Office of Research Infrastructure Programs | |
| Southwest National Primate Research Center | P51 OD011133 |
| Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health | |
| NIH Office of the Director | P51OD011133 |
| National Institute of Allergy and Infectious Diseases | R01 AI117862 |
Keywords
- cytomegalovirus
- inclusions
- intra-cytoplasmic
- intranuclear
- model
- non-human primate
- pituitary
- viral
ASJC Scopus subject areas
- Animal Science and Zoology
- General Veterinary
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