Cytomegaloviruses use multiple mechanisms to elude the host immune response

Emmanuel Wiertz, Ann Hill, Dominic Tortorella, Hidde Ploegh

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The study of the effects of cytomegaloviruses on the MHC class I- restricted antigen presentation pathway has yielded an embarrassment of riches. The human cytomegalovirus (HCMV) encodes at least five to six different glycoproteins, each interfering in a different way with elimination of the virus by the host immune system. Most likely, it is the concerted action of these glycoproteins that allows HCMV to escape from elimination by the host immune system during acute and perhaps also persistent infection. Prime targets of these CMV glycoproteins are MHC class I glycoproteins: the very molecules that signal the presence of a virally infected cell to the immune system. Recently, several novel links in the multi-step process of immune evasion by HCMV have been discovered.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalImmunology Letters
Issue number1-3
StatePublished - 1997


  • Cytomegalovirus
  • Immune system
  • MHC class I

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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