@article{41812479ca504e10beb4642c635982ae,
title = "d-Amphetamine: Disruptive effects on the long-term store of memory and proactive facilitatory effects on learning in inbred mice",
abstract = "Male, C57BL/6J mice were given two daily trials on an appetitively-motivated successive brightness discrimination maze problem; they then received daily intraperitoneal injections of saline or d-amphetamine for 5 days. When trained again in the maze, mice in all d-amphetamine groups tended to display impaired retention: retention was significantly impaired in the 2.0 mg/kg group. Naive mice were treated exactly as were the pretrained mice except that they received no initial maze training prior to drug treatments. Mice in all naive d-amphetamine groups tended to display enhanced acquisition of the maze problem: acquisition was significantly enhanced in the 1.0 mg/kg group. These results could not be explained as effects of d-amphetamine on attentional, motivational or other performance factors.",
keywords = "Facilitation of learning, Inbred mice, Learning, Long-term store of memory, Memory, Memory disruption, Proactive facilitation, d-Amphetamine",
author = "Crabbe, {John C.} and Alpern, {Herbert P.}",
note = "Funding Information: Recently, neural excitants have been shown to affect the long-term store of memory itself, as distinguished from memory consolidation processes \[1, 8, 30\]. Alpern and Crabbe found that, after exposure to a maze, 10 daily administrations of a low dosage of strychnine sulphate facilitated retention of the maze problem in mice \[1 \]. The first injection was administered 24 hr after initial training, well beyond the temporal limits for retrograde facilitation of the consolidation process with strychnine \[26\]. In addition, when the same injection series was administered to animals that had not been partially trained in the maze, no enhancement of acquisition was observed. Thus, the enhancement seen in pretrained animals could not have resulted from proactive facilitation of learning ability, and the results were interpreted to indicate an effect of the drug on the 1This investigation was supported by National Institute of Mental Health Grant MH 11167. Appreciation is expressed to Smith, Kline, and French Laboratories for their generosity in supplying the d-amphetamine employed in these experiments. 2The data reported were included in a doctoral dissertation submitted to the Department of Psychology, University of Colorado. Current address: Department of Psychology, San Jose State University, San Jose, California 95192.",
year = "1975",
doi = "10.1016/0091-3057(75)90186-0",
language = "English (US)",
volume = "3",
pages = "647--652",
journal = "Pharmacology, Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",
}