TY - JOUR
T1 - D-dimer is not elevated in asymptomatic high altitude climbers after descent to 5340m
T2 - The mount everest deep venous thrombosis study (Ev-DVT)
AU - Zafren, Ken
AU - Feldman, Joanne
AU - Becker, Robert J.
AU - Williams, Sarah R.
AU - Weiss, Eric A.
AU - Deloughery, Tom
PY - 2011/10/1
Y1 - 2011/10/1
N2 - Zafren, Ken, Joane Feldman, Robert J. Becker, Sarah R. Williams, Eric A Weiss, and Tom Deloughery. D-dimer is not elevated in asymptomatic high altitude climbers after descent to 5340 meters: the Mount Everest deep venous thrombosis study (Ev-DVT). High Alt. Med. Biol. 12:223-227, 2011.-We performed this study to determine the prevalence of elevated D-dimer, a marker for deep venous thrombosis (DVT), in asymptomatic high altitude climbers. On-site personnel enrolled a convenience sample of climbers at Mt. Everest Base Camp (Nepal), elevation 5340m (17,500ft), during a single spring climbing season. Subjects were enrolled after descent to base camp from higher elevation. The subjects completed a questionnaire to evaluate their risk factors for DVT. We then performed a D-dimer test in asymptomatic individuals. If the D-dimer test was negative, DVT was considered ruled out. Ultrasound was available to perform lower-extremity compression ultrasounds to evaluate for DVT in case the D-dimer was positive. We enrolled 76 high altitude climbers. None had a positive D-dimer test. The absence of positive D-dimer tests suggests a low prevalence of DVT in asymptomatic high altitude climbers.
AB - Zafren, Ken, Joane Feldman, Robert J. Becker, Sarah R. Williams, Eric A Weiss, and Tom Deloughery. D-dimer is not elevated in asymptomatic high altitude climbers after descent to 5340 meters: the Mount Everest deep venous thrombosis study (Ev-DVT). High Alt. Med. Biol. 12:223-227, 2011.-We performed this study to determine the prevalence of elevated D-dimer, a marker for deep venous thrombosis (DVT), in asymptomatic high altitude climbers. On-site personnel enrolled a convenience sample of climbers at Mt. Everest Base Camp (Nepal), elevation 5340m (17,500ft), during a single spring climbing season. Subjects were enrolled after descent to base camp from higher elevation. The subjects completed a questionnaire to evaluate their risk factors for DVT. We then performed a D-dimer test in asymptomatic individuals. If the D-dimer test was negative, DVT was considered ruled out. Ultrasound was available to perform lower-extremity compression ultrasounds to evaluate for DVT in case the D-dimer was positive. We enrolled 76 high altitude climbers. None had a positive D-dimer test. The absence of positive D-dimer tests suggests a low prevalence of DVT in asymptomatic high altitude climbers.
KW - D-dimer
KW - coagulation
KW - deep venous thrombosis
KW - high altitude
KW - hypoxia
KW - venous thromboembolism
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U2 - 10.1089/ham.2010.1101
DO - 10.1089/ham.2010.1101
M3 - Article
C2 - 21962065
AN - SCOPUS:80053492499
SN - 1527-0297
VL - 12
SP - 223
EP - 227
JO - High Altitude Medicine and Biology
JF - High Altitude Medicine and Biology
IS - 3
ER -