Abstract
The D4 dopamine receptor is activated by the catecholamine dopamine and is a member of the rhodopsin-like 7-transmembrane superfamily of receptors. D4 receptors belong to the D2-like dopamine receptor subfamily, which consists of the D2, D3, and D4 receptors. D4 receptors are found both post- and pre-synaptically in the nervous system and couple to heterotrimeric G i/o proteins to inhibit adenylate cyclase and/or calcium channels or modulate potassium channels. The D4 receptor, along with the D3 receptor, is less abundant in comparison to the D2 receptor.
| Original language | English (US) |
|---|---|
| Title of host publication | xPharm |
| Subtitle of host publication | The Comprehensive Pharmacology Reference |
| Publisher | Elsevier Inc. |
| Pages | 1-12 |
| Number of pages | 12 |
| ISBN (Print) | 9780080552323 |
| DOIs | |
| State | Published - 2007 |
| Externally published | Yes |
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)