D4 dopamine receptor

Kim Neve, David R. Sibley

Research output: Chapter in Book/Report/Conference proceedingChapter


The D4 dopamine receptor is activated by the catecholamine dopamine and is a member of the rhodopsin-like 7-transmembrane superfamily of receptors. D4 receptors belong to the D2-like dopamine receptor subfamily, which consists of the D2, D3, and D4 receptors. D4 receptors are found both post- and pre-synaptically in the nervous system and couple to heterotrimeric G i/o proteins to inhibit adenylate cyclase and/or calcium channels or modulate potassium channels. The D4 receptor, along with the D3 receptor, is less abundant in comparison to the D2 receptor.

Original languageEnglish (US)
Title of host publicationxPharm
Subtitle of host publicationThe Comprehensive Pharmacology Reference
PublisherElsevier Inc.
Number of pages12
ISBN (Print)9780080552323
StatePublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)


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