Daily rhythm of plasma melatonin in normal and precocious puberty

Joel R.L. Ehrenkranz, Lawrence Tamarkin, Florence Comite, Roger E. Johnsonbaugh, David E. Bybee, D. Lynn Loriaux, Gordon B. Cutler

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


A previous study of normal humans has shown a decrease in plasma melatonin at the onset of puberty, suggesting that melatonin may act to restrain pubertal onset. We have measured plasma melatonin throughout a 24-h period in normal and constitutionally short males at different pubertal stages and in patients with idiopathic true precocious puberty and familial male isosexual precocity. The 24-h profile of plasma melatonin was similar for the prepubertal, pubertal, and adult males studied, with all subjects having low levels (20–50 pg/ml) during the day and high levels (80–100 pg/ml) at night between 0100–0500 h. The 24-h profiles of the patients with isosexual precocity were similar to the profiles observed throughout normal puberty. These data do not support a role for melatonin in the initiation of normal or precocious puberty in man.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number2
StatePublished - Aug 1982
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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