TY - JOUR
T1 - DASH for asthma
T2 - A pilot study of the DASH diet in not-well-controlled adult asthma
AU - Ma, Jun
AU - Strub, Peg
AU - Lavori, Phillip W.
AU - Buist, A. Sonia
AU - Camargo, Carlos A.
AU - Nadeau, Kari C.
AU - Wilson, Sandra R.
AU - Xiao, Lan
N1 - Funding Information:
Dr. Camargo has received financial support from a variety of groups for participation in conferences, consulting, and medical research. During 2005 to 2010, industry sponsors with an interest in asthma were AstraZeneca, Critical Therapeutics, Dey, Genentech, GSK, Merck, Novartis, Respironics, and Schering-Plough. Dr. Buist is, or has been recently, a member of advisory boards for AstraZeneca, Merck, GSK, Sepracor, Pfizer and Novartis.
PY - 2013/7
Y1 - 2013/7
N2 - This pilot study aims to provide effect size confidence intervals, clinical trial and intervention feasibility data, and procedural materials for a full-scale randomized controlled trial that will determine the efficacy of Dietary Approaches to Stop Hypertension (DASH) as adjunct therapy to standard care for adults with uncontrolled asthma. The DASH diet encompasses foods (e.g., fresh fruit, vegetables, and nuts) and antioxidant nutrients (e.g., vitamins A, C, E, and zinc) with potential benefits for persons with asthma, but it is unknown whether the whole diet is beneficial. Participants (n = 90) will be randomized to receive usual care alone or combined with a DASH intervention consisting of 8 group and 3 individual sessions during the first 3. months, followed by at least monthly phone consultations for another 3. months. Follow-up assessments will occur at 3 and 6. months. The primary outcome measure is the 7-item Juniper Asthma Control Questionnaire, a validated composite measure of daytime and nocturnal symptoms, activity limitations, rescue medication use, and percentage predicted forced expiratory volume in 1. second. We will explore changes in inflammatory markers important to asthma pathophysiology (e.g., fractional exhaled nitric oxide) and their potential to mediate the intervention effect on disease control. We will also conduct pre-specified subgroup analyses by genotype (e.g., polymorphisms on the glutathione S transferase gene) and phenotype (e.g., atopy, obesity). By evaluating a dietary pattern approach to improving asthma control, this study could advance the evidence base for refining clinical guidelines and public health recommendations regarding the role of dietary modifications in asthma management.
AB - This pilot study aims to provide effect size confidence intervals, clinical trial and intervention feasibility data, and procedural materials for a full-scale randomized controlled trial that will determine the efficacy of Dietary Approaches to Stop Hypertension (DASH) as adjunct therapy to standard care for adults with uncontrolled asthma. The DASH diet encompasses foods (e.g., fresh fruit, vegetables, and nuts) and antioxidant nutrients (e.g., vitamins A, C, E, and zinc) with potential benefits for persons with asthma, but it is unknown whether the whole diet is beneficial. Participants (n = 90) will be randomized to receive usual care alone or combined with a DASH intervention consisting of 8 group and 3 individual sessions during the first 3. months, followed by at least monthly phone consultations for another 3. months. Follow-up assessments will occur at 3 and 6. months. The primary outcome measure is the 7-item Juniper Asthma Control Questionnaire, a validated composite measure of daytime and nocturnal symptoms, activity limitations, rescue medication use, and percentage predicted forced expiratory volume in 1. second. We will explore changes in inflammatory markers important to asthma pathophysiology (e.g., fractional exhaled nitric oxide) and their potential to mediate the intervention effect on disease control. We will also conduct pre-specified subgroup analyses by genotype (e.g., polymorphisms on the glutathione S transferase gene) and phenotype (e.g., atopy, obesity). By evaluating a dietary pattern approach to improving asthma control, this study could advance the evidence base for refining clinical guidelines and public health recommendations regarding the role of dietary modifications in asthma management.
KW - Asthma
KW - Asthma Control Questionnaire
KW - DASH
KW - Dietary pattern
KW - Lung function
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UR - http://www.scopus.com/inward/citedby.url?scp=84878451127&partnerID=8YFLogxK
U2 - 10.1016/j.cct.2013.04.008
DO - 10.1016/j.cct.2013.04.008
M3 - Article
C2 - 23648395
AN - SCOPUS:84878451127
SN - 1551-7144
VL - 35
SP - 55
EP - 67
JO - Contemporary Clinical Trials
JF - Contemporary Clinical Trials
IS - 2
ER -