Daytime eating prevents internal circadian misalignment and glucose intolerance in night work

Sarah L. Chellappa; Jingyi Qian; Nina Vujovic; Christopher J. Morris; Arlet Nedeltcheva; Hoa Nguyen; Nishath Rahman; Su Wei Heng; Lauren Kelly; Kayla Kerlin-Monteiro; Suhina Srivastav; Wei Wang; Daniel Aeschbach; Charles A. Czeisler; Steven A. Shea; Gail K. Adler; Marta Garaulet; Frank A.J.L. Scheer

doi:10.1126/sciadv.abg9910

Daytime eating prevents internal circadian misalignment and glucose intolerance in night work

Sarah L. Chellappa, Jingyi Qian, Nina Vujovic, Christopher J. Morris, Arlet Nedeltcheva, Hoa Nguyen, Nishath Rahman, Su Wei Heng, Lauren Kelly, Kayla Kerlin-Monteiro, Suhina Srivastav, Wei Wang, Daniel Aeschbach, Charles A. Czeisler, Steven A. Shea, Gail K. Adler, Marta Garaulet, Frank A.J.L. Scheer

Oregon Institute of Occupational Health Sciences

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Night work increases diabetes risk. Misalignment between the central circadian “clock” and daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal misalignment between central and peripheral circadian rhythms. Whether appropriate circadian alignment of eating can prevent internal circadian misalignment and glucose intolerance is unknown. In a 14-day circadian paradigm, we assessed glycemic control during simulated night work with either nighttime or daytime eating. Assessment of central (body temperature) and peripheral (glucose and insulin) endogenous circadian rhythms happened during constant routine protocols before and after simulated night work. Nighttime eating led to misalignment between central and peripheral (glucose) endogenous circadian rhythms and impaired glucose tolerance, whereas restricting meals to daytime prevented it. These findings offer a behavioral approach to preventing glucose intolerance in shift workers.

Original language	English (US)
Article number	eabg9910
Journal	Science Advances
Volume	7
Issue number	49
DOIs	https://doi.org/10.1126/sciadv.abg9910
State	Published - Dec 2021

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Chellappa, S. L., Qian, J., Vujovic, N., Morris, C. J., Nedeltcheva, A., Nguyen, H., Rahman, N., Heng, S. W., Kelly, L., Kerlin-Monteiro, K., Srivastav, S., Wang, W., Aeschbach, D., Czeisler, C. A., Shea, S. A., Adler, G. K., Garaulet, M., & Scheer, F. A. J. L. (2021). Daytime eating prevents internal circadian misalignment and glucose intolerance in night work. Science Advances, 7(49), Article eabg9910. https://doi.org/10.1126/sciadv.abg9910

Chellappa, SL, Qian, J, Vujovic, N, Morris, CJ, Nedeltcheva, A, Nguyen, H, Rahman, N, Heng, SW, Kelly, L, Kerlin-Monteiro, K, Srivastav, S, Wang, W, Aeschbach, D, Czeisler, CA, Shea, SA, Adler, GK, Garaulet, M & Scheer, FAJL 2021, 'Daytime eating prevents internal circadian misalignment and glucose intolerance in night work', Science Advances, vol. 7, no. 49, eabg9910. https://doi.org/10.1126/sciadv.abg9910

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title = "Daytime eating prevents internal circadian misalignment and glucose intolerance in night work",

abstract = "Night work increases diabetes risk. Misalignment between the central circadian “clock” and daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal misalignment between central and peripheral circadian rhythms. Whether appropriate circadian alignment of eating can prevent internal circadian misalignment and glucose intolerance is unknown. In a 14-day circadian paradigm, we assessed glycemic control during simulated night work with either nighttime or daytime eating. Assessment of central (body temperature) and peripheral (glucose and insulin) endogenous circadian rhythms happened during constant routine protocols before and after simulated night work. Nighttime eating led to misalignment between central and peripheral (glucose) endogenous circadian rhythms and impaired glucose tolerance, whereas restricting meals to daytime prevented it. These findings offer a behavioral approach to preventing glucose intolerance in shift workers.",

author = "Chellappa, {Sarah L.} and Jingyi Qian and Nina Vujovic and Morris, {Christopher J.} and Arlet Nedeltcheva and Hoa Nguyen and Nishath Rahman and Heng, {Su Wei} and Lauren Kelly and Kayla Kerlin-Monteiro and Suhina Srivastav and Wei Wang and Daniel Aeschbach and Czeisler, {Charles A.} and Shea, {Steven A.} and Adler, {Gail K.} and Marta Garaulet and Scheer, {Frank A.J.L.}",

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language = "English (US)",

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AU - Nguyen, Hoa

AU - Rahman, Nishath

AU - Heng, Su Wei

AU - Kelly, Lauren

AU - Kerlin-Monteiro, Kayla

AU - Srivastav, Suhina

AU - Wang, Wei

AU - Aeschbach, Daniel

AU - Czeisler, Charles A.

AU - Shea, Steven A.

AU - Adler, Gail K.

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AB - Night work increases diabetes risk. Misalignment between the central circadian “clock” and daily behaviors, typical in night workers, impairs glucose tolerance, likely due to internal misalignment between central and peripheral circadian rhythms. Whether appropriate circadian alignment of eating can prevent internal circadian misalignment and glucose intolerance is unknown. In a 14-day circadian paradigm, we assessed glycemic control during simulated night work with either nighttime or daytime eating. Assessment of central (body temperature) and peripheral (glucose and insulin) endogenous circadian rhythms happened during constant routine protocols before and after simulated night work. Nighttime eating led to misalignment between central and peripheral (glucose) endogenous circadian rhythms and impaired glucose tolerance, whereas restricting meals to daytime prevented it. These findings offer a behavioral approach to preventing glucose intolerance in shift workers.

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Daytime eating prevents internal circadian misalignment and glucose intolerance in night work

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