Abstract
The effect of highly active antiretroviral therapy (HAART) on HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals was studied. Subjects receiving treatment for over a year were compared with individuals not receiving therapy. The absolute number of HIV-specific memory CD4 T cells proliferating in response to HIV antigen was substantially higher in untreated subjects than in those on HAART. A decrease in HIV-specific memory CD4 T cells could explain the rebound in HIV replication after the termination of HAART.
Original language | English (US) |
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Pages (from-to) | 1885-1887 |
Number of pages | 3 |
Journal | AIDS |
Volume | 15 |
Issue number | 14 |
DOIs | |
State | Published - Sep 28 2001 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases