Decreased HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals on antiretroviral therapy

Smita A. Ghanekar; Sharon A. Stranford; June C. Ong; Joshua M. Walker; Vernon C. Maino; Jay A. Levy

doi:10.1097/00002030-200109280-00021

Decreased HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals on antiretroviral therapy

Smita A. Ghanekar, Sharon A. Stranford, June C. Ong, Joshua M. Walker, Vernon C. Maino, Jay A. Levy

Radiation Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The effect of highly active antiretroviral therapy (HAART) on HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals was studied. Subjects receiving treatment for over a year were compared with individuals not receiving therapy. The absolute number of HIV-specific memory CD4 T cells proliferating in response to HIV antigen was substantially higher in untreated subjects than in those on HAART. A decrease in HIV-specific memory CD4 T cells could explain the rebound in HIV replication after the termination of HAART.

Original language	English (US)
Pages (from-to)	1885-1887
Number of pages	3
Journal	AIDS
Volume	15
Issue number	14
DOIs	https://doi.org/10.1097/00002030-200109280-00021
State	Published - Sep 28 2001

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/00002030-200109280-00021

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abstract = "The effect of highly active antiretroviral therapy (HAART) on HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals was studied. Subjects receiving treatment for over a year were compared with individuals not receiving therapy. The absolute number of HIV-specific memory CD4 T cells proliferating in response to HIV antigen was substantially higher in untreated subjects than in those on HAART. A decrease in HIV-specific memory CD4 T cells could explain the rebound in HIV replication after the termination of HAART.",

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AU - Ghanekar, Smita A.

AU - Stranford, Sharon A.

AU - Ong, June C.

AU - Walker, Joshua M.

AU - Maino, Vernon C.

AU - Levy, Jay A.

PY - 2001/9/28

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AB - The effect of highly active antiretroviral therapy (HAART) on HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals was studied. Subjects receiving treatment for over a year were compared with individuals not receiving therapy. The absolute number of HIV-specific memory CD4 T cells proliferating in response to HIV antigen was substantially higher in untreated subjects than in those on HAART. A decrease in HIV-specific memory CD4 T cells could explain the rebound in HIV replication after the termination of HAART.

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Decreased HIV-specific CD4 T cell proliferation in long-term HIV-infected individuals on antiretroviral therapy

Abstract

ASJC Scopus subject areas

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