Defining the steps in a multistep mouse model for mammary carcinogenesis

H. E. Varmus, L. A. Godley, S. Roy, I. C.A. Taylor, L. Yuschenkoff, Y. P. Shi -, D. Pinkel, J. Gray, R. Pyle, C. M. Aldaz, A. Bradley, D. Medina, L. A. Donehower

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The Wnt-1 transgenic system has provided a rich model for studying mammary tumorigenesis in the mouse. Crossing these animals to other transgenic animals and infecting them with MMTV have forcefully demonstrated the synergy between Wnt-1 and members of the Fgf family. Mammary tumors from Wnt-1 TG/p53-deficient mice present novel features: a less fibrotic histology, rapid kinetics of tumor formation, and increased genomic instability. Understanding the molecular basis for such phenotypes may provide insights into the behavior of human tumors, especially those in which p53 has been affected.

Original languageEnglish (US)
Pages (from-to)491-499
Number of pages9
JournalCold Spring Harbor symposia on quantitative biology
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics


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