Delayed intracranial hypertension after cranial vault remodeling for nonsyndromic single-suture synostosis

Justin S. Cetas, Morad Nasseri, Targol Saedi, Anna A. Kuang, Nathan R. Selden

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Object. Delayed intracranial hypertension may occur after cranial vault remodeling for synostosis and may result in visual loss and developmental delay. Delayed intracranial hypertension is relatively common in children with syndromic, multisuture synostosis, but the incidence is poorly defined in children with single-suture nonsyndromic synostosis. This study evaluates the frequency of reoperation for delayed intracranial hypertension after single-suture synostosis repair. Methods. Patients who had undergone cranial vault remodeling for nonsyndromic single-suture synostosis and were treated at a single tertiary pediatric hospital between July 2000 and December 2010 were analyzed for the occurrence of delayed intracranial hypertension and reoperation for cranial vault remodeling. Results. Eighty-one patients with clinical follow-up of at least 3 years were analyzed from a total of 156 consecutive patients. The average patient age at the initial operation was 9.1 months. Five (6.2%) of 81 patients presented with delayed clinical and ophthalmological signs and symptoms of intracranial hypertension following initial cranial vault reconstruction, confirmed indirectly in each case by CT findings and directly by intracranial pressure monitoring. These 5 patients underwent repeat cranial vault reconstruction. Conclusions. Calvarial growth restriction and intracranial hypertension occur sporadically following primary cranial vault reconstruction for single-suture nonsyndromic cranial synostosis. In this series, delayed intracranial hypertension occurred only in male patients who underwent primary repair of isolated sagittal synostoses at an age less than or equal to 5 months.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalJournal of Neurosurgery: Pediatrics
Issue number6
StatePublished - Jun 2013


  • Congenital
  • Cranial synostosis
  • Cranial vault reconstruction
  • Funduscopy
  • Intracranial hypertension
  • Intracranial pressure

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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