Abstract
It has been hypothesized that a rearrangement between the δ recombining element (δRec) and a pseudo Jα gene serves to delete the TCR-δ locus before rearrangement of the TCR-α genes. We have now sequenced a direct, site-specific rearrangement between the δRec element and a pseudo Jα gene in a human leukemic stem-cell line. Putative 'N-sequence' addition was noted at the site of recombination, suggesting that this even occurred at the time when the enzyme(s) involved in N-region addition were active in this cell. This provides support for the view that deletion of the TCR-δ locus is required before rearrangement of the TCR-α chain genes.
Original language | English (US) |
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Pages (from-to) | 339-342 |
Number of pages | 4 |
Journal | Journal of Experimental Medicine |
Volume | 170 |
Issue number | 1 |
DOIs | |
State | Published - 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology