Abstract
Serotonin (5-HT)-stimulated phosphoinositide hydrolysis in the choroid plexus is mediated by the 5-HT-1c receptor. The current study demonstrates that treatment of rats with the serotonergic neurotoxin, 5,7-dihydroxytryptamine, caused a marked depletion of 5-HT and a supersensitive 5-HT-1c mediated phosphoinositide hydrolysis response. These data suggest that the 5-HT-1c site in choroid plexus receives tonic serotonergic input.
Original language | English (US) |
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Pages (from-to) | 396-398 |
Number of pages | 3 |
Journal | Brain research |
Volume | 400 |
Issue number | 2 |
DOIs | |
State | Published - Jan 6 1987 |
Externally published | Yes |
Keywords
- 5-HT-1c receptor
- Cerebrospinal fluid
- Choroid plexus
- Phosphoinositide hydrolysis
- Serotonergic denervation
- Serotonin receptor
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology