Depression among needle exchange program and methadone maintenance clients

Rebecca S. Brienza, Michael D. Stein, Mei Hsiu Chen, Aruna Gogineni, Mindy Sobota, Jina Maksad, Ping Hu, Jennifer Clarke

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


The objective of this study was to compare the prevalence of major depression in two cohorts of injection drug users, those enrolled in a Rhode Island Methadone Maintenance Treatment Program (MMTP) and those enrolled in a Rhode Island Needle Exchange Program (NEP) using cross-sectional interviews. Symptomatic and duration criteria for major depression in the last 6 months were identified using the Structured Clinical Interview for DSM-III-R (SCID). Among 528 persons interviewed, 54% of those in NEP and 42% of those in MMTP met criteria for major depression. Using multivariate logistic regression, women (odds ratio [OR] 2.5; 95% confidence interval [CI] 1.7-3.7), persons with alcohol use disorders (OR 1.7; 95% CI 1.1-2.7), and persons without a current partner (OR 1.8; 95% CI 1.2-2.6) were more likely to be depressed controlling for age, race, education and HIV status. Persons enrolled in MMTP were less likely to be depressed (OR 0.6; 95% CI 0.4-0.8) than NEP. Higher rates of depression were found among NEP attendees than among those enrolled in MMTP. Mental health referrals should be part of the growing number of needle exchanges in the United States. (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)331-337
Number of pages7
JournalJournal of Substance Abuse Treatment
Issue number4
StatePublished - Jun 2000
Externally publishedYes


  • Depression
  • Methadone
  • Needle exchange

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health


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