Depression: Cause or Complication of Cognitive Decline?

David Mansoor, Sahana Misra, Linda Ganzini

Research output: Chapter in Book/Report/Conference proceedingChapter


Depression may be a risk factor, prodrome, correlate or outcome of dementia. Proposed pathways linking depression with dementia include vascular disease, hippocampal atrophy, and proinflammatory changes. Depression is neither a normal nor expected development in old age, but the prevalence increases with increasing burden of medical illness in the older patient. New depression in old age often portends development of dementia.

Original languageEnglish (US)
Title of host publicationDementia
Number of pages10
ISBN (Electronic)9781118656082
ISBN (Print)9780470674246
StatePublished - Oct 28 2013
Externally publishedYes


  • Alzheimer's disease
  • Antidepressant
  • Apathy
  • Cortisol
  • Dementia
  • Depression
  • Pseudodementia
  • Psychostimulant
  • Suicide
  • Vascular

ASJC Scopus subject areas

  • Medicine(all)


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