TY - JOUR
T1 - Depressive Symptoms in Children with Chronic Kidney Disease
AU - Chronic Kidney Disease in Children (CKiD) Study Group
AU - Kogon, Amy J.
AU - Matheson, Matthew B.
AU - Flynn, Joseph T.
AU - Gerson, Arlene C.
AU - Warady, Bradley A.
AU - Furth, Susan L.
AU - Hooper, Stephen R.
AU - Dart, Allison
AU - Greenbaum, Larry
AU - Goebel, Jens
AU - Mitsnefes, Mark
AU - Wong, Craig
AU - Fathallah, Sahar
AU - Salusky, Isidro
AU - Yadin, Ora
AU - Dell, Katherine
AU - Morgenstern, Bruce
AU - Blydt-Hansen, Tom
AU - Pan, Cynthia
AU - Davis, Keefe
AU - Al-Uzri, Amira
AU - Jenkins, Randall
AU - Portale, Anthony
AU - Seikaly, Mouin
AU - Turman, Martin
AU - Wong, Cynthia
AU - Alexander, Steven
AU - Hastings, Colleen
AU - Rodig, Nancy
AU - Harmon, William
AU - Bartosh, Sharon
AU - Benador, Nadine
AU - Mak, Robert
AU - Wood, Ellen
AU - Lerner, Gary
AU - Massengill, Susan
AU - Hidalgo, Guillermo
AU - Atkinson, Meredith
AU - Gipson, Debbie
AU - Srivaths, Poyyapakkam
AU - Samuels, Joshua
AU - Kaskel, Frederick
AU - Mattosian, Debora
AU - Cai, Yi
AU - Andreoli, Sharon
AU - Saland, Jeffrey
AU - Norwood, Victoria
AU - Parekh, Rulan
AU - Robinson, Lisa
AU - Mendley, Susan
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objective To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL). Study design Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the effects of CDI score on longitudinal changes in glomerular filtration rate and time to renal replacement therapy. Results A total of 344 subjects completed the CDI. Eighteen (5%) had elevated depressive symptoms, and another 7 (2%) were being treated for depression. In adjusted analyses, maternal education beyond high school was associated with 5% lower CDI scores (estimate, 0.95; 95% CI, 0.92-0.99). Depression status was associated with lower IQ (99 vs 88; P =.053), lower achievement (95 vs 77.5; P <.05), and lower HRQoL by parent and child reports (effect estimates, -15.48; 95% CI, -28.71 to -2.24 and -18.39; 95% CI, -27.81 to -8.96, respectively). CDI score was not related to change in glomerular filtration rate. Conclusion Children with depression had lower psychoeducational skills and worse HRQoL. Identifying and treating depression should be evaluated as a means of improving the academic performance and HRQoL of children with chronic kidney disease.
AB - Objective To assess depression in children with chronic kidney disease and to determine associations with patient characteristics, intellectual and educational levels, and health-related quality of life (HRQoL). Study design Subjects aged 6-17 years from the Chronic Kidney Disease in Children cohort study completed the Children's Depression Inventory (CDI), Wechsler Abbreviated Scales of Intelligence, Wechsler Individual Achievement Test-II-Abbreviated, and the Pediatric Inventory of Quality of Life Core Scales 4.0. Regression analyses determined associations of CDI score and depression status with subject characteristics, intellectual and educational levels, and HRQoL. A joint linear mixed model and Weibull model were used to determine the effects of CDI score on longitudinal changes in glomerular filtration rate and time to renal replacement therapy. Results A total of 344 subjects completed the CDI. Eighteen (5%) had elevated depressive symptoms, and another 7 (2%) were being treated for depression. In adjusted analyses, maternal education beyond high school was associated with 5% lower CDI scores (estimate, 0.95; 95% CI, 0.92-0.99). Depression status was associated with lower IQ (99 vs 88; P =.053), lower achievement (95 vs 77.5; P <.05), and lower HRQoL by parent and child reports (effect estimates, -15.48; 95% CI, -28.71 to -2.24 and -18.39; 95% CI, -27.81 to -8.96, respectively). CDI score was not related to change in glomerular filtration rate. Conclusion Children with depression had lower psychoeducational skills and worse HRQoL. Identifying and treating depression should be evaluated as a means of improving the academic performance and HRQoL of children with chronic kidney disease.
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U2 - 10.1016/j.jpeds.2015.09.040
DO - 10.1016/j.jpeds.2015.09.040
M3 - Article
C2 - 26505290
AN - SCOPUS:84955677487
SN - 0022-3476
VL - 168
SP - 164-170.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -