Abstract
An endoscopic photoacoustic probe is designed and tested for use in PDT treatment of esophageal cancer. The probe, measuring less than 2.5 mm in diameter, was designed to fit within the lumen of an endoscope that will be inserted into an esophagous after PDT. PDT treatment results in a blanched, necrotic layer of cancerous tissue over a healthy, deeper layer of perfused tissue. The photoacoustic probe was designed to use acoustic propagation time to determine the thickness of the blanched surface of the esophagous, which corresponds to treatment depth. A side-firing 600 μm fiber delivered 532nm laser light to induce acoustic waves in the perfused layer of the esophagous beneath the blanched (treated) layer. A PVDF transducer detected the induced acoustic waves and transmitted the signal to an oscilloscope. The probe was tested on clear and turbid tissue phantom layers over an optically absorbing dye solution.
Original language | English (US) |
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Pages (from-to) | 16-27 |
Number of pages | 12 |
Journal | Proceedings of SPIE - The International Society for Optical Engineering |
Volume | 4256 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Acoustic
- Nd:YAG
- Optical fiber
- PVDF
- Propagation time
- Q-switched
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering