Development of the olfactory nerve: Its relationship to the craniofacies

Stephen R. Braddock, Marjorie R. Grafe, Kenneth L. Jones

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Although absence of the olfactory bulbs is a relatively common occurrence seen in holoprosencephaly, in Kallman syndrome, and in a number of malformation syndromes, the extent to which it determines olfactory nerve development, as well as the part it plays in the morphogenesis of the nasal structures, is unknown. Cases of arhinencephaly ascertained at autopsy were studied in an effort to better understand the relationships between the olfactory nerve, bulb, and facies. Based on these studies, it is concluded that both olfactory receptor cells and olfactory nerves are present in arhinencephaly, that the olfactory nerves did not make contact with the brain in these cases, that the presence of olfactory nerves is independent of the severity of the central nervous system malformation, and that the shape of the nasal sturctures is not dependent on the presence of the olfactory nerve. © 1995 WiIey‐Liss, Inc. © 1995 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
Issue number4
StatePublished - Apr 1995
Externally publishedYes

ASJC Scopus subject areas

  • Embryology
  • Toxicology
  • Developmental Biology
  • Health, Toxicology and Mutagenesis


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