Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord

L. Zubeldia-Brenner; C. E. Roselli; S. E. Recabarren; M. C. Gonzalez Deniselle; H. E. Lara

doi:10.1111/jne.12401

Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord

L. Zubeldia-Brenner, C. E. Roselli, S. E. Recabarren, M. C. Gonzalez Deniselle, H. E. Lara

Chemical Physiology and Biochemistry

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual orientation, reproductive and metabolic programming, and the neuroendocrine mechanism involved in the development of polycystic ovary syndrome phenotype. Moreover, consistent with the wide range of processes in which steroid hormones take part, we discuss the protective effects of progesterone on neurodegenerative disease and the signalling mechanism involved in the genesis of oestrogen-induced pituitary prolactinomas.

Original language	English (US)
Journal	Journal of Neuroendocrinology
Volume	28
Issue number	7
DOIs	https://doi.org/10.1111/jne.12401
State	Published - Jul 1 2016

Keywords

androgens
hormonal programming
oestrogens
prolactin
steroid hormones

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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10.1111/jne.12401

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title = "Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord",

abstract = "This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual orientation, reproductive and metabolic programming, and the neuroendocrine mechanism involved in the development of polycystic ovary syndrome phenotype. Moreover, consistent with the wide range of processes in which steroid hormones take part, we discuss the protective effects of progesterone on neurodegenerative disease and the signalling mechanism involved in the genesis of oestrogen-induced pituitary prolactinomas.",

keywords = "androgens, hormonal programming, oestrogens, prolactin, steroid hormones",

author = "L. Zubeldia-Brenner and Roselli, {C. E.} and Recabarren, {S. E.} and {Gonzalez Deniselle}, {M. C.} and Lara, {H. E.}",

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AU - Roselli, C. E.

AU - Recabarren, S. E.

AU - Gonzalez Deniselle, M. C.

AU - Lara, H. E.

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N2 - This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual orientation, reproductive and metabolic programming, and the neuroendocrine mechanism involved in the development of polycystic ovary syndrome phenotype. Moreover, consistent with the wide range of processes in which steroid hormones take part, we discuss the protective effects of progesterone on neurodegenerative disease and the signalling mechanism involved in the genesis of oestrogen-induced pituitary prolactinomas.

AB - This review highlights the principal effects of steroid hormones at central and peripheral levels in the neuroendocrine axis. The data discussed highlight the principal role of oestrogens and testosterone in hormonal programming in relation to sexual orientation, reproductive and metabolic programming, and the neuroendocrine mechanism involved in the development of polycystic ovary syndrome phenotype. Moreover, consistent with the wide range of processes in which steroid hormones take part, we discuss the protective effects of progesterone on neurodegenerative disease and the signalling mechanism involved in the genesis of oestrogen-induced pituitary prolactinomas.

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KW - oestrogens

KW - prolactin

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Developmental and Functional Effects of Steroid Hormones on the Neuroendocrine Axis and Spinal Cord

Abstract

Keywords

ASJC Scopus subject areas

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