@inbook{5b5ceecdac294d729de1b5cb0fa69535,
title = "Developmental Neurotoxicity of Alcohol: Effects and Mechanisms of Ethanol on the Developing Brain",
abstract = "Fetal alcohol spectrum disorders (FASD) encompasses all the consequences of maternal alcohol consumption during pregnancy in the offspring. Central nervous system dysfunctions and structural and functional brain abnormalities are the most deleterious consequences of prenatal alcohol exposure leading to cognitive and behavioral impairment that affect individuals throughout life. This chapter describes the cognitive, neurobehavioral, and brain structural abnormalities identified in humans following in utero alcohol exposure. This chapter also describes FASD animal models used in research to increase the understanding of the consequences of alcohol exposure during gestation on the developing brain. Finally, this chapter describes the cellular/molecular mechanisms involved in the developmental neurotoxicity of alcohol as well as the interventions that have been proposed and are currently under investigation to improve the consequences of in utero alcohol exposure.",
keywords = "Animal models, Apoptosis, Brain, Epigenetics, Fetal alcohol spectrum disorders, Fetal development, Glial cells, Neurobehavioral deficits, Neuronal plasticity, Neurons",
author = "Xiaolu Zhang and Hashimoto, {Joel G.} and Marina Guizzetti",
note = "Funding Information: This work was supported by VA Merit Review Award # I01BX001819 and by NIH/NIAAA R01AA021468, and R01AA022948 to M.G. and by facilities and resources at the VA Portland Health Care System (M.G.). The opinions expressed in this paper are solely those of the authors. The contents do not represent the views of the US Department of Veterans Affairs or the US government. The authors are extremely grateful to Mr. Jeff Frkonja for the graphic design of Fig. 1. Funding Information: This work was supported by VA Merit Review Award # I01BX001819 and by NIH/NIAAA R01AA021468 , and R01AA022948 to M.G. and by facilities and resources at the VA Portland Health Care System (M.G.). The opinions expressed in this paper are solely those of the authors. The contents do not represent the views of the US Department of Veterans Affairs or the US government. The authors are extremely grateful to Mr. Jeff Frkonja for the graphic design of Fig. 1 . Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = jan,
doi = "10.1016/bs.ant.2018.03.006",
language = "English (US)",
series = "Advances in Neurotoxicology",
publisher = "Elsevier Inc.",
pages = "115--144",
booktitle = "Linking Environmental Exposure to Neurodevelopmental Disorders",
}