Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer

Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030. Considering the failure to date to efficiently treat existing PDAC, increased effort should be undertaken to prevent this disease. A better understanding of the risk factors leading to PDAC development is of utmost importance to identify and formulate preventive strategies. Large epidemiologic and cohort studies have identified risk factors for the development of PDAC, including obesity and type 2 diabetes mellitus. This review highlights the current knowledge of obesity and type 2 diabetes as risk factors for PDAC development and progression, their interplay and underlying mechanisms, and the relation to diet. Research gaps and opportunities to address this deadly disease are also outlined.

Original languageEnglish (US)
Pages (from-to)555-567
Number of pages13
JournalJournal of the Academy of Nutrition and Dietetics
Issue number4
StatePublished - Apr 2018


  • Obesity
  • Pancreatic cancer
  • Prevention
  • Review
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


Dive into the research topics of 'Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer'. Together they form a unique fingerprint.

Cite this