Abstract
Proteinopathies, associated with the development of dementia, are characterized by both systemic inflammation and neuroinflammation. This sustained/unresolved immune response involves a large number of inflammatory mediators that ultimately may be responsible for the neuronal deficits that underlie cognitive dysfunction. Our research and that of others have demonstrated elevated levels of diacylglycerols in the brain and plasma of patients with proteinopathies. We conclude that these metabolic products of phospholipases C and D are lipid biomarkers of unresolved immune pathology. Since diacylglycerols serve both structural and signal transduction roles, elevations in the levels of these normally tightly regulated lipids may contribute to neuronal dysfunction in proteinopathies.
Original language | English (US) |
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Title of host publication | Diagnosis and Management in Dementia |
Subtitle of host publication | The Neuroscience of Dementia, Volume 1 |
Publisher | Elsevier |
Pages | 255-262 |
Number of pages | 8 |
ISBN (Electronic) | 9780128158548 |
DOIs | |
State | Published - Jan 1 2020 |
Keywords
- Alzheimer’s disease
- Diacylglycerols
- Lewy body disease
- Neuroinflammation
- Parkinson’s disease
ASJC Scopus subject areas
- General Medicine
- General Neuroscience