TY - JOUR
T1 - Diagnosing autism
T2 - Analyses of data from the autism diagnostic interview
AU - Lord, Catherine
AU - Pickles, Andrew
AU - McLennan, John
AU - Rutter, Michael
AU - Bregman, Joel
AU - Folstein, Susan
AU - Fombonne, Eric
AU - Leboyer, Marion
AU - Minshew, Nancy
N1 - Funding Information:
1This research was supported by the National Institute of Mental Health K05 MH01196, MH19726, and a grant from the John D. and Catherine T. MacArthur Foundation in association with the DSM-IV Field Trials to the first author. 2Address all correspondence to Catherine Lord, Department of Psychiatry, University of Chicago, 5841 South Maryland Avenue, MC 3077, Chicago, Illinois 60637.
PY - 1997
Y1 - 1997
N2 - Results from ROC curves of items from two scales, the Autism Diagnostic Interview (ADI) and Autism Diagnostic Interview-Revised (ADI-R), operationalizing DSM-IV criteria for autism are presented for 319 autistic and 113 other subjects from 8 international autism centers. Analyses indicate that multiple items were necessary to attain adequate sensitivity and specificity if samples with varying levels of language were considered separately. Although considering only current behavior was generally sufficient when a combination cutoff and additive model was employed, predictive power was highest when history was taken into account. A single set of criteria, as operationalized by individually structured questions in the ADI/ADI-R, was effective in differentiating autism from mental handicap and language impairment in subjects with a range of chronological ages and developmental levels.
AB - Results from ROC curves of items from two scales, the Autism Diagnostic Interview (ADI) and Autism Diagnostic Interview-Revised (ADI-R), operationalizing DSM-IV criteria for autism are presented for 319 autistic and 113 other subjects from 8 international autism centers. Analyses indicate that multiple items were necessary to attain adequate sensitivity and specificity if samples with varying levels of language were considered separately. Although considering only current behavior was generally sufficient when a combination cutoff and additive model was employed, predictive power was highest when history was taken into account. A single set of criteria, as operationalized by individually structured questions in the ADI/ADI-R, was effective in differentiating autism from mental handicap and language impairment in subjects with a range of chronological ages and developmental levels.
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U2 - 10.1023/A:1025873925661
DO - 10.1023/A:1025873925661
M3 - Article
C2 - 9403369
AN - SCOPUS:0030773652
SN - 0162-3257
VL - 27
SP - 501
EP - 517
JO - Journal of autism and developmental disorders
JF - Journal of autism and developmental disorders
IS - 5
ER -