TY - JOUR
T1 - Diagnostic methods for myalgic encephalomyelitis/chronic fatigue syndrome
T2 - A systematic review for a national institutes of health pathways to prevention workshop
AU - Haney, Elizabeth
AU - Beth Smith, M. E.
AU - McDonagh, Marian
AU - Pappas, Miranda
AU - Daeges, Monica
AU - Wasson, Ngoc
AU - Nelson, Heidi
N1 - Publisher Copyright:
© 2015 American College of Physicians.
PY - 2015/6/16
Y1 - 2015/6/16
N2 - Background: The diagnosis of myalgic encephalomyelitis (ME)/ chronic fatigue syndrome (CFS) is based on clinical criteria, yet there has been no consensus regarding which set of criteria best identifies patients with the condition. The Institute of Medicine has recently proposed a new case definition and diagnostic algorithm. Purpose: To review methods to diagnose ME/CFS in adults and identify research gaps and needs for future research. Data Sources: MEDLINE, PsycINFO, and Cochrane databases (January 1988 to September 2014); clinical trial registries; and reference lists. Study Selection: English-language studies describing methods of diagnosis of ME/CFS and their accuracy. Data Extraction: Data on participants, study design, analysis, follow-up, and results were extracted and confirmed. Study quality was dual-rated by using prespecified criteria, and discrepancies were resolved through consensus. Data Synthesis: Forty-four studies met inclusion criteria. Eight case definitions have been used to define ME/CFS; a ninth, recently proposed by the Institute of Medicine, includes principal elements of previous definitions. Patients meeting criteria for ME represent a more symptomatic subset of the broader ME/CFS population. Scales rating self-reported symptoms differentiate patients with ME/CFS from healthy controls under study conditions but have not been evaluated in clinically undiagnosed patients to determine validity and generalizability.
AB - Background: The diagnosis of myalgic encephalomyelitis (ME)/ chronic fatigue syndrome (CFS) is based on clinical criteria, yet there has been no consensus regarding which set of criteria best identifies patients with the condition. The Institute of Medicine has recently proposed a new case definition and diagnostic algorithm. Purpose: To review methods to diagnose ME/CFS in adults and identify research gaps and needs for future research. Data Sources: MEDLINE, PsycINFO, and Cochrane databases (January 1988 to September 2014); clinical trial registries; and reference lists. Study Selection: English-language studies describing methods of diagnosis of ME/CFS and their accuracy. Data Extraction: Data on participants, study design, analysis, follow-up, and results were extracted and confirmed. Study quality was dual-rated by using prespecified criteria, and discrepancies were resolved through consensus. Data Synthesis: Forty-four studies met inclusion criteria. Eight case definitions have been used to define ME/CFS; a ninth, recently proposed by the Institute of Medicine, includes principal elements of previous definitions. Patients meeting criteria for ME represent a more symptomatic subset of the broader ME/CFS population. Scales rating self-reported symptoms differentiate patients with ME/CFS from healthy controls under study conditions but have not been evaluated in clinically undiagnosed patients to determine validity and generalizability.
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U2 - 10.7326/M15-0443
DO - 10.7326/M15-0443
M3 - Review article
C2 - 26075754
AN - SCOPUS:84932097882
SN - 0003-4819
VL - 162
SP - 834
EP - 840
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 12
ER -