Dietary amino acid-induced systemic lupus erythematosus

A. Montanaro, E. J. Bardana

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


The effects of dietary manipulations on autoimmune disease are understood poorly. In this article, we detail our experience with a human subject who developed autoimmune hemolytic anemia while participating in a research study that required the ingestion of alfalfa seeds. Subsequent experimentalstudies in primates ingesting alfalfa sprout seeds and L-canavanine (a prominent amino acid constituent of alfalfa) is presented. The results of these studies indicate a potential toxic and immunoregulatory role of L-canavanine in the induction of a systemic lupus-like disease in primates.

Original languageEnglish (US)
Pages (from-to)323-332+x
JournalRheumatic Disease Clinics of North America
Issue number2
StatePublished - 1991

ASJC Scopus subject areas

  • Rheumatology


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