TY - JOUR
T1 - Dietary calcium improves bone mineral density (BMD) and lowers blood pressure (BP) in spontaneously hypertensive rats (SHR)
AU - Roullet, C. M.
AU - Orwoll, E.
AU - Roullet, Jean-Baptiste
AU - Yue, Q.
AU - McCarron, D. A.
AU - Hatton, D. C.
PY - 1997/12/1
Y1 - 1997/12/1
N2 - An increase in calcium intake has been proposed as a non-pharmacological treatment of high BP. Moreover, an inverse relationship has been observed between bone mineral content and BP. We therefore postulated that dietary Ca2+ improves Ca2+ homeostasis, restoring BMD and BP to normal, and measured BP (mmHg), BMD (mg/area), calcitriol (D, pg/ml), PTH (pg/ml), ionized Ca2+ (iCa, mM) and CaBP-9K (μg/mg, a marker of intestinal Ca2+ transport) in SHR fed 0.1%, 0.2%, 1.0% or 2.0% Ca2+ diets for 6 weeks (n=16/group, half SHR provided by Taconic (T), and half by Chartes River (CR). Results were: (*, p<0.05, ANOVA) m±SEM 0.1% Ca 0.2% Ca 1.0% Ca 2.0% Ca BP* 212.6±4.0 211.9±3.8 200.1±3.8 176.6±4.7 iCa * 1.26±0.02 1.33±0.01 1.35±0.01 1.34±0.01 D * 503.5±7.0 182.2±8.2 92.9±4.7 96.2±3.3 CaBP * 34.6±1.7 28.1±1.5 20.4±1.1 17.4±1.1 BMD * 89±2 108±2 133±2 135±2 PTH T * 211.5±25.8 164.9±21.8 106.9±10.2 83.4±11.4 CR 134.0±46.0 118.6±24.2 159.7±20.1 105.1±12.5 The following correlations were found: iCa/D (P<0.0001, r=-0.54); iCa/PTH (p<0.0002, r=-0.48), BMD/D (p<0.0001, r=-0.84), BMD/BP (p<0.0006, r=-0.47), BMD/CABP (p<0.0001, r=-0.75), and D/CaBP (p<0.0001, r=0.70). The data suggest that increased calcium intake improves calcium homeostasis as well as systemic BP and BMD, thus supporting the hypothesis that essential hypertension can be successfully treated with adequate Ca2+ intake.
AB - An increase in calcium intake has been proposed as a non-pharmacological treatment of high BP. Moreover, an inverse relationship has been observed between bone mineral content and BP. We therefore postulated that dietary Ca2+ improves Ca2+ homeostasis, restoring BMD and BP to normal, and measured BP (mmHg), BMD (mg/area), calcitriol (D, pg/ml), PTH (pg/ml), ionized Ca2+ (iCa, mM) and CaBP-9K (μg/mg, a marker of intestinal Ca2+ transport) in SHR fed 0.1%, 0.2%, 1.0% or 2.0% Ca2+ diets for 6 weeks (n=16/group, half SHR provided by Taconic (T), and half by Chartes River (CR). Results were: (*, p<0.05, ANOVA) m±SEM 0.1% Ca 0.2% Ca 1.0% Ca 2.0% Ca BP* 212.6±4.0 211.9±3.8 200.1±3.8 176.6±4.7 iCa * 1.26±0.02 1.33±0.01 1.35±0.01 1.34±0.01 D * 503.5±7.0 182.2±8.2 92.9±4.7 96.2±3.3 CaBP * 34.6±1.7 28.1±1.5 20.4±1.1 17.4±1.1 BMD * 89±2 108±2 133±2 135±2 PTH T * 211.5±25.8 164.9±21.8 106.9±10.2 83.4±11.4 CR 134.0±46.0 118.6±24.2 159.7±20.1 105.1±12.5 The following correlations were found: iCa/D (P<0.0001, r=-0.54); iCa/PTH (p<0.0002, r=-0.48), BMD/D (p<0.0001, r=-0.84), BMD/BP (p<0.0006, r=-0.47), BMD/CABP (p<0.0001, r=-0.75), and D/CaBP (p<0.0001, r=0.70). The data suggest that increased calcium intake improves calcium homeostasis as well as systemic BP and BMD, thus supporting the hypothesis that essential hypertension can be successfully treated with adequate Ca2+ intake.
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M3 - Article
AN - SCOPUS:33750275807
SN - 0892-6638
VL - 11
SP - A468
JO - FASEB Journal
JF - FASEB Journal
IS - 3
ER -