Diplopia and HMG-CoA reductase inhibitors

F. W. Fraunfelder, F. T. Fraunfelder, Ralph Edwards

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Seventy-one cases of possible diplopia associated with cholesterol- lowering, HMG-CoA reductase inhibitors lovastatin, simvastatin, pravastatin, or fluvastatin are reviewed. Cases were received from spontaneous reporting systems, and while these data are incomplete, two cases recurred on rechallenge and 31 had positive dechallenge tests. This suggests that these agents may cause diplopia in some patients. Diplopia may be a potential marker of these agents' drug-induced, generalized muscle dysfunction.

Original languageEnglish (US)
Pages (from-to)287-289
Number of pages3
JournalJournal of Toxicology - Cutaneous and Ocular Toxicology
Issue number4
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Toxicology
  • Health, Toxicology and Mutagenesis


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