DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Margie N. Sutton; Zhen Lu; Yao Cheng Li; Yong Zhou; Tao Huang; Albert S. Reger; Amy M. Hurwitz; Timothy Palzkill; Craig Logsdon; Xiaowen Liang; Joe W. Gray; Xiaolin Nan; John Hancock; Geoffrey M. Wahl; Robert C. Bast

doi:10.1016/j.celrep.2019.11.045

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Margie N. Sutton, Zhen Lu, Yao Cheng Li, Yong Zhou, Tao Huang, Albert S. Reger, Amy M. Hurwitz, Timothy Palzkill, Craig Logsdon, Xiaowen Liang, Joe W. Gray, Xiaolin Nan, John Hancock, Geoffrey M. Wahl, Robert C. Bast

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Sutton et. al. show that re-expression of DIRAS3 can inhibit the growth of multiple cancer types driven by K-RAS mutations by a direct interaction and disruption of K-RAS higher ordered clusters. This phenotype is driven by an N-terminal extension, which distinguishes DIRAS3 from other RAS-related small GTPases.

Original language	English (US)
Pages (from-to)	3448-3459.e6
Journal	Cell Reports
Volume	29
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2019.11.045
State	Published - Dec 10 2019

Keywords

ARHI
DIRAS3
RAS inhibitor
cluster
dimer
heteromer
ovarian cancer
pancreatic cancer
transformation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2019.11.045

Cite this

@article{3d821e42acb942aeb9cf8b353cda634c,

title = "DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters",

abstract = "Sutton et. al. show that re-expression of DIRAS3 can inhibit the growth of multiple cancer types driven by K-RAS mutations by a direct interaction and disruption of K-RAS higher ordered clusters. This phenotype is driven by an N-terminal extension, which distinguishes DIRAS3 from other RAS-related small GTPases.",

keywords = "ARHI, DIRAS3, RAS inhibitor, cluster, dimer, heteromer, ovarian cancer, pancreatic cancer, transformation",

author = "Sutton, {Margie N.} and Zhen Lu and Li, {Yao Cheng} and Yong Zhou and Tao Huang and Reger, {Albert S.} and Hurwitz, {Amy M.} and Timothy Palzkill and Craig Logsdon and Xiaowen Liang and Gray, {Joe W.} and Xiaolin Nan and John Hancock and Wahl, {Geoffrey M.} and Bast, {Robert C.}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = dec,

day = "10",

doi = "10.1016/j.celrep.2019.11.045",

language = "English (US)",

volume = "29",

pages = "3448--3459.e6",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "11",

}

TY - JOUR

T1 - DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

AU - Sutton, Margie N.

AU - Lu, Zhen

AU - Li, Yao Cheng

AU - Zhou, Yong

AU - Huang, Tao

AU - Reger, Albert S.

AU - Hurwitz, Amy M.

AU - Palzkill, Timothy

AU - Logsdon, Craig

AU - Liang, Xiaowen

AU - Gray, Joe W.

AU - Nan, Xiaolin

AU - Hancock, John

AU - Wahl, Geoffrey M.

AU - Bast, Robert C.

PY - 2019/12/10

Y1 - 2019/12/10

N2 - Sutton et. al. show that re-expression of DIRAS3 can inhibit the growth of multiple cancer types driven by K-RAS mutations by a direct interaction and disruption of K-RAS higher ordered clusters. This phenotype is driven by an N-terminal extension, which distinguishes DIRAS3 from other RAS-related small GTPases.

AB - Sutton et. al. show that re-expression of DIRAS3 can inhibit the growth of multiple cancer types driven by K-RAS mutations by a direct interaction and disruption of K-RAS higher ordered clusters. This phenotype is driven by an N-terminal extension, which distinguishes DIRAS3 from other RAS-related small GTPases.

KW - ARHI

KW - DIRAS3

KW - RAS inhibitor

KW - cluster

KW - dimer

KW - heteromer

KW - ovarian cancer

KW - pancreatic cancer

KW - transformation

UR - http://www.scopus.com/inward/record.url?scp=85076047191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076047191&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.11.045

DO - 10.1016/j.celrep.2019.11.045

M3 - Article

C2 - 31825828

AN - SCOPUS:85076047191

SN - 2211-1247

VL - 29

SP - 3448-3459.e6

JO - Cell Reports

JF - Cell Reports

IS - 11

ER -

DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this